Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp
Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal a...
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| Veröffentlicht in: | Folia microbiologica 2001, Vol.46 (2), p.107-111 |
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| creator | VOLLEKOVA, A KOSTALOVA, D SOCHOROVAC, R |
| description | Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range ≤50–≥1000 mg/L. |
| doi_str_mv | 10.1007/BF02873586 |
| format | Article |
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The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range ≤50–≥1000 mg/L.</description><identifier>ISSN: 0015-5632</identifier><identifier>EISSN: 1874-9356</identifier><identifier>DOI: 10.1007/BF02873586</identifier><identifier>PMID: 11501395</identifier><identifier>CODEN: FOMIAZ</identifier><language>eng</language><publisher>Praha: Springer Netherlands</publisher><subject>Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; antifungal properties ; bark ; berberine ; bioassays ; Biological and medical sciences ; Dermatomycoses - microbiology ; fractionation ; Fundamental and applied biological sciences. Psychology ; iodides ; Isoquinolines - isolation & purification ; Isoquinolines - pharmacology ; Mahonia - chemistry ; Malassezia - drug effects ; Medical sciences ; Microbial Sensitivity Tests ; Microbiology ; Mycology ; Pathogenicity, host-agent relations, miscellaneous strains, epidemiology ; Pharmacology. 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The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range ≤50–≥1000 mg/L.</description><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>antifungal properties</subject><subject>bark</subject><subject>berberine</subject><subject>bioassays</subject><subject>Biological and medical sciences</subject><subject>Dermatomycoses - microbiology</subject><subject>fractionation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>iodides</subject><subject>Isoquinolines - isolation & purification</subject><subject>Isoquinolines - pharmacology</subject><subject>Mahonia - chemistry</subject><subject>Malassezia - drug effects</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mycology</subject><subject>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pityriasis - microbiology</subject><subject>Plant Bark - chemistry</subject><issn>0015-5632</issn><issn>1874-9356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1Lw0AQBuBFFFurF3-A5qK36OxnNkctVgsVD9qLlzBJduvafJlNBP31LljxNDDzzMC8hJxSuKIAyfXtAphOuNRqj0ypTkSccqn2yRSAylgqzibkyPt3AAWCs0MyoVQC5amcktelbz9G17SVa0yE1Rar1pU-sn1bR4_41jYOIwzCBjHWkR9MHeXYbyPsgy8G9xnKBl3jh-Ar9N58hxXfdcfkwGLlzcmuzsh6cfcyf4hXT_fL-c0qtkzRIeZlUVoKWnHJAEFIlso8YcxY1FJIRaUQKRVpTm1SlJqnoaHLEo0oCy2LhM_I5e_drg-vGD9ktfOFqSpsTDv6LAnHQVEI8GwHx7w2Zdb1rsb-K_tLI4CLHUBfYGV7bArn_52gCqjmwZ3_Ootthps-mPUzgzANEaecU_4DOet2Fg</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>VOLLEKOVA, A</creator><creator>KOSTALOVA, D</creator><creator>SOCHOROVAC, R</creator><general>Springer Netherlands</general><general>Academia</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp</title><author>VOLLEKOVA, A ; KOSTALOVA, D ; SOCHOROVAC, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f261t-3dcdf10863520a045295b722efa8545615449149b1f7cd8391548ddae4dc85c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>antifungal properties</topic><topic>bark</topic><topic>berberine</topic><topic>bioassays</topic><topic>Biological and medical sciences</topic><topic>Dermatomycoses - microbiology</topic><topic>fractionation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>iodides</topic><topic>Isoquinolines - isolation & purification</topic><topic>Isoquinolines - pharmacology</topic><topic>Mahonia - chemistry</topic><topic>Malassezia - drug effects</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Mycology</topic><topic>Pathogenicity, host-agent relations, miscellaneous strains, epidemiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pityriasis - microbiology</topic><topic>Plant Bark - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VOLLEKOVA, A</creatorcontrib><creatorcontrib>KOSTALOVA, D</creatorcontrib><creatorcontrib>SOCHOROVAC, R</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Folia microbiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VOLLEKOVA, A</au><au>KOSTALOVA, D</au><au>SOCHOROVAC, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp</atitle><jtitle>Folia microbiologica</jtitle><addtitle>Folia Microbiol (Praha)</addtitle><date>2001</date><risdate>2001</risdate><volume>46</volume><issue>2</issue><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0015-5632</issn><eissn>1874-9356</eissn><coden>FOMIAZ</coden><abstract>Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range ≤50–≥1000 mg/L.</abstract><cop>Praha</cop><pub>Springer Netherlands</pub><pmid>11501395</pmid><doi>10.1007/BF02873586</doi><tpages>5</tpages></addata></record> |
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| ispartof | Folia microbiologica, 2001, Vol.46 (2), p.107-111 |
| issn | 0015-5632 1874-9356 |
| language | eng |
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| subjects | Alkaloids - isolation & purification Alkaloids - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - isolation & purification Antifungal Agents - pharmacology antifungal properties bark berberine bioassays Biological and medical sciences Dermatomycoses - microbiology fractionation Fundamental and applied biological sciences. Psychology iodides Isoquinolines - isolation & purification Isoquinolines - pharmacology Mahonia - chemistry Malassezia - drug effects Medical sciences Microbial Sensitivity Tests Microbiology Mycology Pathogenicity, host-agent relations, miscellaneous strains, epidemiology Pharmacology. Drug treatments Pityriasis - microbiology Plant Bark - chemistry |
| title | Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp |
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