Inhibition of p38 mitogen activated protein kinase increases lipopolysaccharide induced inhibition of apoptosis in neutrophils by activating extracellular signal-regulated kinase

Background. Prolonged polymorphonuclear neutrophil (PMN) survival has been implicated in tissue injury after sepsis. Previously we reported that lipopolysaccharide (LPS) inhibits PMN apoptosis via the activation of the extracellular signal-regulated kinase (ERK). Conversely, the p38 mitogen activate...

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Veröffentlicht in:	Surgery 2001-08, Vol.130 (2), p.242-248
Hauptverfasser:	Sheth, Ketan, Friel, John, Nolan, Brian, Bankey, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis - drug effects Apoptosis - immunology Bacterial diseases Biological and medical sciences Enzyme Inhibitors - pharmacology Flavonoids - pharmacology General aspects Humans Imidazoles - pharmacology Infectious diseases Lipopolysaccharides - pharmacology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Medical sciences Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Neutrophils - cytology Neutrophils - enzymology p38 Mitogen-Activated Protein Kinases Phosphorylation Pyridines - pharmacology
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