Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia
This study compares intrathecal (IT) fentanyl with IV ondansetron for preventing intraoperative nausea and vomiting during cesarean deliveries performed with spinal anesthesia. Thirty healthy parturients presenting for elective cesarean delivery with standardized bupivacaine spinal anesthesia were r...
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Veröffentlicht in: | Anesthesia and analgesia 2000-05, Vol.90 (5), p.1162-1166 |
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description | This study compares intrathecal (IT) fentanyl with IV ondansetron for preventing intraoperative nausea and vomiting during cesarean deliveries performed with spinal anesthesia. Thirty healthy parturients presenting for elective cesarean delivery with standardized bupivacaine spinal anesthesia were randomized to receive 20 microg IT fentanyl (Group F) or 4 mg IV ondansetron (Group O) by using double-blinded methodology. At eight specific intervals during the surgery, a blinded observer questioned the patient about nausea (1 = nausea, 0 = no nausea), observed for the presence of retching or vomiting (1 = vomiting or retching, 0 = no vomiting or retching), and recorded a verbal pain score (0-10, 0 = no pain, 10 = worst pain imaginable). Cumulative nausea, vomiting, and pain scores were calculated as the sum of the eight measurements. Intraoperative nausea was decreased in the IT fentanyl group compared with the IV ondansetron group: the median (interquartile range) difference in nausea scores was 1 (1, 2), P = 0.03. The incidence of vomiting and treatment for vomiting was not different (P = 0.7). The IT fentanyl group had a lower cumulative perioperative pain score than the IV ondansetron group; the median difference in the cumulative pain score was 12 (8, 16) (P = 0.0007). The IT fentanyl group required less supplementary intraoperative analgesia. The median difference in the cumulative fentanyl dose was 100 (75, 100) microg fentanyl, (P = 0.0002). |
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R ; VISCOMI, C. M ; PACE, N. L</creator><creatorcontrib>MANULLANG, T. R ; VISCOMI, C. M ; PACE, N. L</creatorcontrib><description>This study compares intrathecal (IT) fentanyl with IV ondansetron for preventing intraoperative nausea and vomiting during cesarean deliveries performed with spinal anesthesia. Thirty healthy parturients presenting for elective cesarean delivery with standardized bupivacaine spinal anesthesia were randomized to receive 20 microg IT fentanyl (Group F) or 4 mg IV ondansetron (Group O) by using double-blinded methodology. At eight specific intervals during the surgery, a blinded observer questioned the patient about nausea (1 = nausea, 0 = no nausea), observed for the presence of retching or vomiting (1 = vomiting or retching, 0 = no vomiting or retching), and recorded a verbal pain score (0-10, 0 = no pain, 10 = worst pain imaginable). Cumulative nausea, vomiting, and pain scores were calculated as the sum of the eight measurements. Intraoperative nausea was decreased in the IT fentanyl group compared with the IV ondansetron group: the median (interquartile range) difference in nausea scores was 1 (1, 2), P = 0.03. The incidence of vomiting and treatment for vomiting was not different (P = 0.7). The IT fentanyl group had a lower cumulative perioperative pain score than the IV ondansetron group; the median difference in the cumulative pain score was 12 (8, 16) (P = 0.0007). The IT fentanyl group required less supplementary intraoperative analgesia. The median difference in the cumulative fentanyl dose was 100 (75, 100) microg fentanyl, (P = 0.0002).</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1097/00000539-200005000-00030</identifier><identifier>PMID: 10781472</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject><![CDATA[Adjuvants, Anesthesia - administration & dosage ; Adult ; Analgesics, Opioid - administration & dosage ; Anesthesia, Obstetrical - adverse effects ; Anesthesia, Spinal - adverse effects ; Antiemetics - administration & dosage ; Biological and medical sciences ; Cesarean Section ; Digestive system ; Double-Blind Method ; Female ; Fentanyl - administration & dosage ; Humans ; Injections, Intravenous ; Injections, Spinal ; Medical sciences ; Ondansetron - administration & dosage ; Pharmacology. Drug treatments ; Postoperative Nausea and Vomiting - etiology ; Postoperative Nausea and Vomiting - prevention & control ; Pregnancy]]></subject><ispartof>Anesthesia and analgesia, 2000-05, Vol.90 (5), p.1162-1166</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-6f89a78d1a10cdffd42822f8751340c9b3cc84b8a552fd90d65f7e1f005b14e03</citedby><cites>FETCH-LOGICAL-c390t-6f89a78d1a10cdffd42822f8751340c9b3cc84b8a552fd90d65f7e1f005b14e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1350271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10781472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MANULLANG, T. R</creatorcontrib><creatorcontrib>VISCOMI, C. M</creatorcontrib><creatorcontrib>PACE, N. L</creatorcontrib><title>Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>This study compares intrathecal (IT) fentanyl with IV ondansetron for preventing intraoperative nausea and vomiting during cesarean deliveries performed with spinal anesthesia. Thirty healthy parturients presenting for elective cesarean delivery with standardized bupivacaine spinal anesthesia were randomized to receive 20 microg IT fentanyl (Group F) or 4 mg IV ondansetron (Group O) by using double-blinded methodology. At eight specific intervals during the surgery, a blinded observer questioned the patient about nausea (1 = nausea, 0 = no nausea), observed for the presence of retching or vomiting (1 = vomiting or retching, 0 = no vomiting or retching), and recorded a verbal pain score (0-10, 0 = no pain, 10 = worst pain imaginable). Cumulative nausea, vomiting, and pain scores were calculated as the sum of the eight measurements. Intraoperative nausea was decreased in the IT fentanyl group compared with the IV ondansetron group: the median (interquartile range) difference in nausea scores was 1 (1, 2), P = 0.03. The incidence of vomiting and treatment for vomiting was not different (P = 0.7). The IT fentanyl group had a lower cumulative perioperative pain score than the IV ondansetron group; the median difference in the cumulative pain score was 12 (8, 16) (P = 0.0007). The IT fentanyl group required less supplementary intraoperative analgesia. The median difference in the cumulative fentanyl dose was 100 (75, 100) microg fentanyl, (P = 0.0002).</description><subject>Adjuvants, Anesthesia - administration & dosage</subject><subject>Adult</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anesthesia, Obstetrical - adverse effects</subject><subject>Anesthesia, Spinal - adverse effects</subject><subject>Antiemetics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fentanyl - administration & dosage</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Injections, Spinal</subject><subject>Medical sciences</subject><subject>Ondansetron - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Nausea and Vomiting - etiology</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Pregnancy</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUdtuFDEMjVAR3bb8AsoD4m1KkrkkeUQVl0qVeIHnkTfjdINmM0OSKdof4Xvx7C7QSI4Tn2M78WGMS3ErhdXvxbra2lbqeCCryGrxgm1kq7pKt9ZcsM0aq5S19pJd5fyDrlKY7hW7lEIb2Wi1Yb_vY0lQduhg5B5jgXgYecg8LzOmMCVeJh5WzhPGacl8igPEjCVNkfsV3iGfExJaAoUmz495tEEJT8gjLBmBD0sK8ZE7zJAQIh9wJDQd-K9QdjzPIVJ_iJipXg5ww156GDO-Pvtr9v3Tx293X6qHr5_v7z48VK62olSdNxa0GSRI4Qbvh0YZpbzRrawb4ey2ds40WwNtq_xgxdC1XqP0NLOtbFDU1-zdqe6cpp8Lde_3ITscR3oK_bbXNCnbSUNEcyK6NOWc0PdzCntIh16KftWk_6tJ_0-T_qgJpb4591i2exyeJZ5EIMLbMwEyyeATRBfyf17dCqVl_Qfo75ho</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>MANULLANG, T. R</creator><creator>VISCOMI, C. M</creator><creator>PACE, N. L</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia</title><author>MANULLANG, T. R ; VISCOMI, C. M ; PACE, N. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-6f89a78d1a10cdffd42822f8751340c9b3cc84b8a552fd90d65f7e1f005b14e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adjuvants, Anesthesia - administration & dosage</topic><topic>Adult</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anesthesia, Obstetrical - adverse effects</topic><topic>Anesthesia, Spinal - adverse effects</topic><topic>Antiemetics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fentanyl - administration & dosage</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Injections, Spinal</topic><topic>Medical sciences</topic><topic>Ondansetron - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Nausea and Vomiting - etiology</topic><topic>Postoperative Nausea and Vomiting - prevention & control</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MANULLANG, T. R</creatorcontrib><creatorcontrib>VISCOMI, C. M</creatorcontrib><creatorcontrib>PACE, N. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MANULLANG, T. R</au><au>VISCOMI, C. M</au><au>PACE, N. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>90</volume><issue>5</issue><spage>1162</spage><epage>1166</epage><pages>1162-1166</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>This study compares intrathecal (IT) fentanyl with IV ondansetron for preventing intraoperative nausea and vomiting during cesarean deliveries performed with spinal anesthesia. Thirty healthy parturients presenting for elective cesarean delivery with standardized bupivacaine spinal anesthesia were randomized to receive 20 microg IT fentanyl (Group F) or 4 mg IV ondansetron (Group O) by using double-blinded methodology. At eight specific intervals during the surgery, a blinded observer questioned the patient about nausea (1 = nausea, 0 = no nausea), observed for the presence of retching or vomiting (1 = vomiting or retching, 0 = no vomiting or retching), and recorded a verbal pain score (0-10, 0 = no pain, 10 = worst pain imaginable). Cumulative nausea, vomiting, and pain scores were calculated as the sum of the eight measurements. Intraoperative nausea was decreased in the IT fentanyl group compared with the IV ondansetron group: the median (interquartile range) difference in nausea scores was 1 (1, 2), P = 0.03. The incidence of vomiting and treatment for vomiting was not different (P = 0.7). The IT fentanyl group had a lower cumulative perioperative pain score than the IV ondansetron group; the median difference in the cumulative pain score was 12 (8, 16) (P = 0.0007). The IT fentanyl group required less supplementary intraoperative analgesia. The median difference in the cumulative fentanyl dose was 100 (75, 100) microg fentanyl, (P = 0.0002).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>10781472</pmid><doi>10.1097/00000539-200005000-00030</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adjuvants, Anesthesia - administration & dosage Adult Analgesics, Opioid - administration & dosage Anesthesia, Obstetrical - adverse effects Anesthesia, Spinal - adverse effects Antiemetics - administration & dosage Biological and medical sciences Cesarean Section Digestive system Double-Blind Method Female Fentanyl - administration & dosage Humans Injections, Intravenous Injections, Spinal Medical sciences Ondansetron - administration & dosage Pharmacology. Drug treatments Postoperative Nausea and Vomiting - etiology Postoperative Nausea and Vomiting - prevention & control Pregnancy |
title | Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia |
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