Vav‐1 regulates NK T cell development and NK cell cytotoxicity

The hematopoietic‐specific Rho‐family GTP exchange factor Vav‐1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells.Recent findings suggest that Vav‐1 also forms part of signaling pathways required for natural and antibody dependent...

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Veröffentlicht in:	European journal of immunology 2001-08, Vol.31 (8), p.2403-2410
Hauptverfasser:	Chan, Gordon, Hanke, Thomas, Fischer, Klaus‐Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Cell Cycle Proteins Cell Differentiation Cells, Cultured Cytotoxicity Cytotoxicity, Immunologic - immunology Enzyme Activation Gene Deletion Interleukin-2 - immunology Killer Cells, Natural - cytology Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Count Mice Mice, Inbred C57BL Mice, Knockout Mitogen-Activated Protein Kinases - metabolism NK cell NK T cell Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-vav Receptors, IgG - immunology Vav1 protein Vav‐1
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