Direct interaction between the sympathetic and renin–angiotensin system in myocardial tissue: a microdialysis study in anaesthetised rats

It has been suggested that local activation of the renin–angiotensin system is involved in early stages of myocardial pathophysiology. To date, there is increasing evidence for interactions between the renin–angiotensin system and the sympathetic nervous system; consequently, local sympathetic activ...

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Veröffentlicht in:	Journal of the autonomic nervous system 2000-01, Vol.78 (2), p.117-121
Hauptverfasser:	Teisman, Ard C.H, Westerink, Ben H.C, van Veldhuisen, Dirk J, Scholtens, Egbert, de Zeeuw, Dick, van Gilst, Wiek H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Angiotensin II - metabolism Angiotensin II - pharmacology Angiotensin Receptor Antagonists Animals Antihypertensive Agents - pharmacology Biological and medical sciences Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Heart Heart - drug effects Heart - innervation Heart - physiology Losartan Losartan - pharmacology Male Microdialysis Myocardial microdialysis Myocardium - cytology Myocardium - metabolism Norepinephrine Norepinephrine - blood Rats Rats, Wistar Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin - metabolism Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Sympathetic Nervous System - cytology Sympathetic Nervous System - drug effects Sympathetic Nervous System - metabolism Vasoconstrictor Agents - metabolism Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system
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