Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model
Stroszczynski C, Hosten N, Puls R, et al. Histopathological correlation to MRI findings during and after laser-induced thermotherapy in a pig pancreas model. Invest Radiol 2001;36:413–420. RATIONALE AND OBJECTIVES. To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuou...
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| Veröffentlicht in: | Investigative radiology 2001-07, Vol.36 (7), p.413-421 |
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| creator | Stroszczynski, CHRISTIAN Hosten, NORBERT Puls, RALF Nagel, STEFAN Scholman, HANS J Wlodarczyk, WALDEMAR Oettle, HELMUT Moesta, KURT T Schlag, PETER M Felix, ROLAND |
| description | Stroszczynski C, Hosten N, Puls R, et al. Histopathological correlation to MRI findings during and after laser-induced thermotherapy in a pig pancreas model. Invest Radiol 2001;36:413–420.
RATIONALE AND OBJECTIVES. To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.
METHODS.Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo–fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.
RESULTS.Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10–32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.
CONCLUSIONS.Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects. |
| doi_str_mv | 10.1097/00004424-200107000-00007 |
| format | Article |
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RATIONALE AND OBJECTIVES. To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.
METHODS.Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo–fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.
RESULTS.Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10–32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.
CONCLUSIONS.Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects.</description><identifier>ISSN: 0020-9996</identifier><identifier>EISSN: 1536-0210</identifier><identifier>DOI: 10.1097/00004424-200107000-00007</identifier><identifier>PMID: 11496096</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins, Inc</publisher><subject>Amylases - blood ; Animals ; Female ; Hyperthermia, Induced ; Laser Coagulation - methods ; Laser Therapy ; Lasers - adverse effects ; Lipase - blood ; Magnetic Resonance Imaging - methods ; Models, Animal ; Pancreas - pathology ; Pancreas - surgery ; Swine</subject><ispartof>Investigative radiology, 2001-07, Vol.36 (7), p.413-421</ispartof><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4067-74b9c3cab7eb13708184d4e0dbc1c6b8e76129f0b920e60d41ac833722ed347d3</citedby><cites>FETCH-LOGICAL-c4067-74b9c3cab7eb13708184d4e0dbc1c6b8e76129f0b920e60d41ac833722ed347d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11496096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stroszczynski, CHRISTIAN</creatorcontrib><creatorcontrib>Hosten, NORBERT</creatorcontrib><creatorcontrib>Puls, RALF</creatorcontrib><creatorcontrib>Nagel, STEFAN</creatorcontrib><creatorcontrib>Scholman, HANS J</creatorcontrib><creatorcontrib>Wlodarczyk, WALDEMAR</creatorcontrib><creatorcontrib>Oettle, HELMUT</creatorcontrib><creatorcontrib>Moesta, KURT T</creatorcontrib><creatorcontrib>Schlag, PETER M</creatorcontrib><creatorcontrib>Felix, ROLAND</creatorcontrib><title>Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model</title><title>Investigative radiology</title><addtitle>Invest Radiol</addtitle><description>Stroszczynski C, Hosten N, Puls R, et al. Histopathological correlation to MRI findings during and after laser-induced thermotherapy in a pig pancreas model. Invest Radiol 2001;36:413–420.
RATIONALE AND OBJECTIVES. To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.
METHODS.Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo–fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.
RESULTS.Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10–32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.
CONCLUSIONS.Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects.</description><subject>Amylases - blood</subject><subject>Animals</subject><subject>Female</subject><subject>Hyperthermia, Induced</subject><subject>Laser Coagulation - methods</subject><subject>Laser Therapy</subject><subject>Lasers - adverse effects</subject><subject>Lipase - blood</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Models, Animal</subject><subject>Pancreas - pathology</subject><subject>Pancreas - surgery</subject><subject>Swine</subject><issn>0020-9996</issn><issn>1536-0210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vEzEQhi0EomnhLyCfuC2MP2qvj1WgNFIqKlTOlteeJAZnHexdVf33uCSFEz545FfPzEiPCaEMPjAw-iO0IyWXHQdgoNure4r0C7Jgl0J1wBm8JAsADp0xRp2R81p_NIJrEK_JGWPSKDBqQcpNrFM-uGmXU95G7xJd5lIwuSnmkU6Z3n5b0es4hjhuK_00l1apGwO92kxY6NpVLN1qDLPHQO93WPZ5arc7PNI4Ukfv4pbeudEXdJXe5oDpDXm1cani21O9IN-vP98vb7r11y-r5dW68xKU7rQcjBfeDRoHJjT0rJdBIoTBM6-GHrVi3GxgMBxQQZDM-V4IzTkGIXUQF-T9ce6h5F8z1snuY_WYkhsxz9XqZq5Xl7KB_RH0JddacGMPJe5debQM7JNv--zb_vX9J9Kt9d1pxzzsMfxrPAlugDwCDzk1X_Vnmh-w2B26NO3s__5R_AaN5Yqb</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Stroszczynski, CHRISTIAN</creator><creator>Hosten, NORBERT</creator><creator>Puls, RALF</creator><creator>Nagel, STEFAN</creator><creator>Scholman, HANS J</creator><creator>Wlodarczyk, WALDEMAR</creator><creator>Oettle, HELMUT</creator><creator>Moesta, KURT T</creator><creator>Schlag, PETER M</creator><creator>Felix, ROLAND</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model</title><author>Stroszczynski, CHRISTIAN ; Hosten, NORBERT ; Puls, RALF ; Nagel, STEFAN ; Scholman, HANS J ; Wlodarczyk, WALDEMAR ; Oettle, HELMUT ; Moesta, KURT T ; Schlag, PETER M ; Felix, ROLAND</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4067-74b9c3cab7eb13708184d4e0dbc1c6b8e76129f0b920e60d41ac833722ed347d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amylases - blood</topic><topic>Animals</topic><topic>Female</topic><topic>Hyperthermia, Induced</topic><topic>Laser Coagulation - methods</topic><topic>Laser Therapy</topic><topic>Lasers - adverse effects</topic><topic>Lipase - blood</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Models, Animal</topic><topic>Pancreas - pathology</topic><topic>Pancreas - surgery</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stroszczynski, CHRISTIAN</creatorcontrib><creatorcontrib>Hosten, NORBERT</creatorcontrib><creatorcontrib>Puls, RALF</creatorcontrib><creatorcontrib>Nagel, STEFAN</creatorcontrib><creatorcontrib>Scholman, HANS J</creatorcontrib><creatorcontrib>Wlodarczyk, WALDEMAR</creatorcontrib><creatorcontrib>Oettle, HELMUT</creatorcontrib><creatorcontrib>Moesta, KURT T</creatorcontrib><creatorcontrib>Schlag, PETER M</creatorcontrib><creatorcontrib>Felix, ROLAND</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stroszczynski, CHRISTIAN</au><au>Hosten, NORBERT</au><au>Puls, RALF</au><au>Nagel, STEFAN</au><au>Scholman, HANS J</au><au>Wlodarczyk, WALDEMAR</au><au>Oettle, HELMUT</au><au>Moesta, KURT T</au><au>Schlag, PETER M</au><au>Felix, ROLAND</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model</atitle><jtitle>Investigative radiology</jtitle><addtitle>Invest Radiol</addtitle><date>2001-07</date><risdate>2001</risdate><volume>36</volume><issue>7</issue><spage>413</spage><epage>421</epage><pages>413-421</pages><issn>0020-9996</issn><eissn>1536-0210</eissn><abstract>Stroszczynski C, Hosten N, Puls R, et al. Histopathological correlation to MRI findings during and after laser-induced thermotherapy in a pig pancreas model. Invest Radiol 2001;36:413–420.
RATIONALE AND OBJECTIVES. To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.
METHODS.Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo–fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.
RESULTS.Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10–32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.
CONCLUSIONS.Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11496096</pmid><doi>10.1097/00004424-200107000-00007</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amylases - blood Animals Female Hyperthermia, Induced Laser Coagulation - methods Laser Therapy Lasers - adverse effects Lipase - blood Magnetic Resonance Imaging - methods Models, Animal Pancreas - pathology Pancreas - surgery Swine |
| title | Histopathological Correlation to MRI Findings During and After Laser-Induced Thermotherapy in a Pig Pancreas Model |
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