Osteomyocutaneous flap as a preclinical composite tissue allograft: Swine model
Composite tissue allotransplantation (CTA) constitutes one of the last frontiers of microsurgery. Prior to its clinical application, the long‐term efficacy of modern immunotherapy must be tested in a pre‐clinical CTA model. Based on the concept of osteomyocutaneous forearm flap, we developed a CTA f...
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| Veröffentlicht in: | Microsurgery 2000, Vol.20 (3), p.143-149 |
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| creator | Ren, Xiaoping Shirbacheh, Mansour V. Üstüner, E. Tuncay Zdichavsky, Marty Edelstein, Jean Maldonado, Claudio Breidenbach, Warren C. Frank, Johannes Tobin, Gordon R. Jones, Jon W. Barker, John H. |
| description | Composite tissue allotransplantation (CTA) constitutes one of the last frontiers of microsurgery. Prior to its clinical application, the long‐term efficacy of modern immunotherapy must be tested in a pre‐clinical CTA model. Based on the concept of osteomyocutaneous forearm flap, we developed a CTA flap model in swine. After identifying the vascular territory of the flaps in six pigs (vascular casting), flaps were transplanted from mismatched donor to recipient pigs (n = 6). Rejection was assessed daily by visual inspection and histopathology of biopsy specimens. Recipient pigs were able to ambulate immediately following surgery. There were no flap failures owing to technical or surgical complications. Rejection occurred over a period of 7 days as manifested by edema, cellular infiltration, epidermalysis, and thrombosis. This pre‐clinical flap model is excellent for evaluating the effectiveness of modern immunotherapy because it is anatomically and immunologically relevant and because the minimal morbidity caused to the animal permits long‐term studies. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:143–149 2000 |
| doi_str_mv | 10.1002/(SICI)1098-2752(2000)20:3<143::AID-MICR9>3.0.CO;2-9 |
| format | Article |
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Tuncay ; Zdichavsky, Marty ; Edelstein, Jean ; Maldonado, Claudio ; Breidenbach, Warren C. ; Frank, Johannes ; Tobin, Gordon R. ; Jones, Jon W. ; Barker, John H.</creator><creatorcontrib>Ren, Xiaoping ; Shirbacheh, Mansour V. ; Üstüner, E. Tuncay ; Zdichavsky, Marty ; Edelstein, Jean ; Maldonado, Claudio ; Breidenbach, Warren C. ; Frank, Johannes ; Tobin, Gordon R. ; Jones, Jon W. ; Barker, John H.</creatorcontrib><description>Composite tissue allotransplantation (CTA) constitutes one of the last frontiers of microsurgery. Prior to its clinical application, the long‐term efficacy of modern immunotherapy must be tested in a pre‐clinical CTA model. Based on the concept of osteomyocutaneous forearm flap, we developed a CTA flap model in swine. After identifying the vascular territory of the flaps in six pigs (vascular casting), flaps were transplanted from mismatched donor to recipient pigs (n = 6). Rejection was assessed daily by visual inspection and histopathology of biopsy specimens. Recipient pigs were able to ambulate immediately following surgery. There were no flap failures owing to technical or surgical complications. Rejection occurred over a period of 7 days as manifested by edema, cellular infiltration, epidermalysis, and thrombosis. This pre‐clinical flap model is excellent for evaluating the effectiveness of modern immunotherapy because it is anatomically and immunologically relevant and because the minimal morbidity caused to the animal permits long‐term studies. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:143–149 2000</description><identifier>ISSN: 0738-1085</identifier><identifier>EISSN: 1098-2752</identifier><identifier>DOI: 10.1002/(SICI)1098-2752(2000)20:3<143::AID-MICR9>3.0.CO;2-9</identifier><identifier>PMID: 10790178</identifier><identifier>CODEN: MSRGDQ</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological and medical sciences ; Female ; Graft Rejection ; Male ; Medical sciences ; Miscellaneous ; Models, Biological ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Flaps - immunology ; Surgical Flaps - pathology ; Swine ; Transplantation, Homologous</subject><ispartof>Microsurgery, 2000, Vol.20 (3), p.143-149</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4589-c5069928179eb1fa558b69a3711d30b26db698eac60ce81f700531ebaf26e72c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2752%282000%2920%3A3%3C143%3A%3AAID-MICR9%3E3.0.CO%3B2-9$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2752%282000%2920%3A3%3C143%3A%3AAID-MICR9%3E3.0.CO%3B2-9$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,4026,27930,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1347085$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10790178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Xiaoping</creatorcontrib><creatorcontrib>Shirbacheh, Mansour V.</creatorcontrib><creatorcontrib>Üstüner, E. Tuncay</creatorcontrib><creatorcontrib>Zdichavsky, Marty</creatorcontrib><creatorcontrib>Edelstein, Jean</creatorcontrib><creatorcontrib>Maldonado, Claudio</creatorcontrib><creatorcontrib>Breidenbach, Warren C.</creatorcontrib><creatorcontrib>Frank, Johannes</creatorcontrib><creatorcontrib>Tobin, Gordon R.</creatorcontrib><creatorcontrib>Jones, Jon W.</creatorcontrib><creatorcontrib>Barker, John H.</creatorcontrib><title>Osteomyocutaneous flap as a preclinical composite tissue allograft: Swine model</title><title>Microsurgery</title><addtitle>Microsurgery</addtitle><description>Composite tissue allotransplantation (CTA) constitutes one of the last frontiers of microsurgery. Prior to its clinical application, the long‐term efficacy of modern immunotherapy must be tested in a pre‐clinical CTA model. Based on the concept of osteomyocutaneous forearm flap, we developed a CTA flap model in swine. After identifying the vascular territory of the flaps in six pigs (vascular casting), flaps were transplanted from mismatched donor to recipient pigs (n = 6). Rejection was assessed daily by visual inspection and histopathology of biopsy specimens. Recipient pigs were able to ambulate immediately following surgery. There were no flap failures owing to technical or surgical complications. Rejection occurred over a period of 7 days as manifested by edema, cellular infiltration, epidermalysis, and thrombosis. This pre‐clinical flap model is excellent for evaluating the effectiveness of modern immunotherapy because it is anatomically and immunologically relevant and because the minimal morbidity caused to the animal permits long‐term studies. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:143–149 2000</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Models, Biological</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Flaps - immunology</subject><subject>Surgical Flaps - pathology</subject><subject>Swine</subject><subject>Transplantation, Homologous</subject><issn>0738-1085</issn><issn>1098-2752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoso7rj6F6QXIrsXHU-SpklmF2Gp7lhYLeysuHeHNJNKtZ3WpmWdf29qh1VQ9CYhh-e85-NNEJwRWBIA-upkk6XZKQElIyo4PaEAcEphxc5JzFari-xN9D5Lr9VrtoRlmp_RSD0IFvf8w2ABgsmIgORHwRPnvvh8pYR6HBwREAqIkIsgz91g22bfmnHQO9uOLixr3YXahTrsemvqalcZXYembbrWVYMNh8q50Ya6rtvPvS6HVbi5q3Y2bNqtrZ8Gj0pdO_vscB8HHy_f3qTvoqt8naUXV5GJuVSR4ZAoRSURyhak1JzLIlGaCUK2DAqabP1TWm0SMFaSUgBwRmyhS5pYQQ07Dl7Oul3ffhutG7CpnLF1PQ-Bwo8oYwH_BSmhnPM49uBmBk3fOtfbEru-anS_RwI4GYI4GYLTgnFaME6G-AMZekMQvSH40xAfAExzpKi86vND-bFo7PY3zdkBD7w4ANr5PZe93pnK_eKYH0Jyj93M2F1V2_0frf2zs781Nge8bDTLVv4bfL-X1f1XTAQTHD99WOP6en15e-vTBfsBR-zBDw</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Ren, Xiaoping</creator><creator>Shirbacheh, Mansour V.</creator><creator>Üstüner, E. Tuncay</creator><creator>Zdichavsky, Marty</creator><creator>Edelstein, Jean</creator><creator>Maldonado, Claudio</creator><creator>Breidenbach, Warren C.</creator><creator>Frank, Johannes</creator><creator>Tobin, Gordon R.</creator><creator>Jones, Jon W.</creator><creator>Barker, John H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>Osteomyocutaneous flap as a preclinical composite tissue allograft: Swine model</title><author>Ren, Xiaoping ; Shirbacheh, Mansour V. ; Üstüner, E. 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Graft diseases</topic><topic>Surgical Flaps - immunology</topic><topic>Surgical Flaps - pathology</topic><topic>Swine</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ren, Xiaoping</creatorcontrib><creatorcontrib>Shirbacheh, Mansour V.</creatorcontrib><creatorcontrib>Üstüner, E. 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Tuncay</au><au>Zdichavsky, Marty</au><au>Edelstein, Jean</au><au>Maldonado, Claudio</au><au>Breidenbach, Warren C.</au><au>Frank, Johannes</au><au>Tobin, Gordon R.</au><au>Jones, Jon W.</au><au>Barker, John H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteomyocutaneous flap as a preclinical composite tissue allograft: Swine model</atitle><jtitle>Microsurgery</jtitle><addtitle>Microsurgery</addtitle><date>2000</date><risdate>2000</risdate><volume>20</volume><issue>3</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0738-1085</issn><eissn>1098-2752</eissn><coden>MSRGDQ</coden><abstract>Composite tissue allotransplantation (CTA) constitutes one of the last frontiers of microsurgery. Prior to its clinical application, the long‐term efficacy of modern immunotherapy must be tested in a pre‐clinical CTA model. Based on the concept of osteomyocutaneous forearm flap, we developed a CTA flap model in swine. After identifying the vascular territory of the flaps in six pigs (vascular casting), flaps were transplanted from mismatched donor to recipient pigs (n = 6). Rejection was assessed daily by visual inspection and histopathology of biopsy specimens. Recipient pigs were able to ambulate immediately following surgery. There were no flap failures owing to technical or surgical complications. Rejection occurred over a period of 7 days as manifested by edema, cellular infiltration, epidermalysis, and thrombosis. This pre‐clinical flap model is excellent for evaluating the effectiveness of modern immunotherapy because it is anatomically and immunologically relevant and because the minimal morbidity caused to the animal permits long‐term studies. © 2000 Wiley‐Liss, Inc. MICROSURGERY 20:143–149 2000</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10790178</pmid><doi>10.1002/(SICI)1098-2752(2000)20:3<143::AID-MICR9>3.0.CO;2-9</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Female Graft Rejection Male Medical sciences Miscellaneous Models, Biological Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - immunology Surgical Flaps - pathology Swine Transplantation, Homologous |
| title | Osteomyocutaneous flap as a preclinical composite tissue allograft: Swine model |
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