Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index
Purpose: Hyperfractionated and accelerated radiotherapy without a split was performed to improve the local control probability of early glottic carcinomas. We analyzed the results of this regimen by using the Ki-67 index. Methods and Materials: Over a 12-year period, 85 T1N0M0 glottic cancers and 50...
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| creator | Sakata, Koh-ichi Oouchi, Atushi Nagakura, Hisayasu Akiba, Hidenari Tamakawa, Mistuharu Koito, Kazumitsu Hareyama, Masato Asakura, Kohji Satoh, Masaaki Ohtani, Seiji |
| description | Purpose: Hyperfractionated and accelerated radiotherapy without a split was performed to improve the local control probability of early glottic carcinomas. We analyzed the results of this regimen by using the Ki-67 index.
Methods and Materials: Over a 12-year period, 85 T1N0M0 glottic cancers and 50 T2N0M0 glottic cancers were treated with conventional fractionation (CF) from 1984 to 1989 and with accelerated fractionation (AF) since 1990. The CF program consisted of five daily fractions of 2 Gy per week, for a total of 64 Gy. The AF program consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, for a total of 55 or 58 Gy. The specimens, taken before radiotherapy, were immunohistochemically stained with anti-Ki-67 antibody.
Results: The 5-year local control probability for T1 tumors was 79.6 ± 6.9% with CF treatment, whereas with AF it was 86.9 ± 5.6%. For T2 tumors it was 62.7 ± 12.2% with CF, whereas it was 74.7 ± 7.8% with AF. The difference between CF and AF did not reach the point of statistical significance. However, when T1 tumors had a Ki-67 index lower than 50%, the local control rate achieved with AF was significantly better than that with CF (
p = 0.018). When the tumors had a Ki-67 index that was 50% or more, there was no difference in the local control rate between CF and AF, whether they were T1 or T2. The peak mucosal reactions at the larynx and/or hypopharynx were much more severe and appeared at smaller doses and earlier in AF than in CF. The patients with AF showed no severe late complications.
Conclusions: AF could not obtain statistically significant improvement in local control probability of T1 or T2 glottic carcinomas. |
| doi_str_mv | 10.1016/S0360-3016(00)00409-0 |
| format | Article |
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Methods and Materials: Over a 12-year period, 85 T1N0M0 glottic cancers and 50 T2N0M0 glottic cancers were treated with conventional fractionation (CF) from 1984 to 1989 and with accelerated fractionation (AF) since 1990. The CF program consisted of five daily fractions of 2 Gy per week, for a total of 64 Gy. The AF program consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, for a total of 55 or 58 Gy. The specimens, taken before radiotherapy, were immunohistochemically stained with anti-Ki-67 antibody.
Results: The 5-year local control probability for T1 tumors was 79.6 ± 6.9% with CF treatment, whereas with AF it was 86.9 ± 5.6%. For T2 tumors it was 62.7 ± 12.2% with CF, whereas it was 74.7 ± 7.8% with AF. The difference between CF and AF did not reach the point of statistical significance. However, when T1 tumors had a Ki-67 index lower than 50%, the local control rate achieved with AF was significantly better than that with CF (
p = 0.018). When the tumors had a Ki-67 index that was 50% or more, there was no difference in the local control rate between CF and AF, whether they were T1 or T2. The peak mucosal reactions at the larynx and/or hypopharynx were much more severe and appeared at smaller doses and earlier in AF than in CF. The patients with AF showed no severe late complications.
Conclusions: AF could not obtain statistically significant improvement in local control probability of T1 or T2 glottic carcinomas.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/S0360-3016(00)00409-0</identifier><identifier>PMID: 10758308</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Accelerated fractionation ; Adult ; Aged ; Aged, 80 and over ; Algorithms ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - chemistry ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Dose Fractionation, Radiation ; Female ; Glottis - radiation effects ; Growth fraction ; Humans ; Ki-67 Antigen - analysis ; Ki-67 index ; Laryngeal Neoplasms - chemistry ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - radiotherapy ; Male ; Medical sciences ; Middle Aged ; Mucous Membrane - radiation effects ; Neoplasm Staging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Radiation therapy ; Salvage Therapy ; Stomatitis - etiology ; Survival Analysis ; T1 glottic cancer ; T2 glottic cancer ; Tumors</subject><ispartof>International journal of radiation oncology, biology, physics, 2000-04, Vol.47 (1), p.81-88</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-98b230626355991a9d7be2848f25ef4edd73ac24d8dade66ac6e940931b4bdfe3</citedby><cites>FETCH-LOGICAL-c390t-98b230626355991a9d7be2848f25ef4edd73ac24d8dade66ac6e940931b4bdfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301600004090$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1325694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10758308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakata, Koh-ichi</creatorcontrib><creatorcontrib>Oouchi, Atushi</creatorcontrib><creatorcontrib>Nagakura, Hisayasu</creatorcontrib><creatorcontrib>Akiba, Hidenari</creatorcontrib><creatorcontrib>Tamakawa, Mistuharu</creatorcontrib><creatorcontrib>Koito, Kazumitsu</creatorcontrib><creatorcontrib>Hareyama, Masato</creatorcontrib><creatorcontrib>Asakura, Kohji</creatorcontrib><creatorcontrib>Satoh, Masaaki</creatorcontrib><creatorcontrib>Ohtani, Seiji</creatorcontrib><title>Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose: Hyperfractionated and accelerated radiotherapy without a split was performed to improve the local control probability of early glottic carcinomas. We analyzed the results of this regimen by using the Ki-67 index.
Methods and Materials: Over a 12-year period, 85 T1N0M0 glottic cancers and 50 T2N0M0 glottic cancers were treated with conventional fractionation (CF) from 1984 to 1989 and with accelerated fractionation (AF) since 1990. The CF program consisted of five daily fractions of 2 Gy per week, for a total of 64 Gy. The AF program consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, for a total of 55 or 58 Gy. The specimens, taken before radiotherapy, were immunohistochemically stained with anti-Ki-67 antibody.
Results: The 5-year local control probability for T1 tumors was 79.6 ± 6.9% with CF treatment, whereas with AF it was 86.9 ± 5.6%. For T2 tumors it was 62.7 ± 12.2% with CF, whereas it was 74.7 ± 7.8% with AF. The difference between CF and AF did not reach the point of statistical significance. However, when T1 tumors had a Ki-67 index lower than 50%, the local control rate achieved with AF was significantly better than that with CF (
p = 0.018). When the tumors had a Ki-67 index that was 50% or more, there was no difference in the local control rate between CF and AF, whether they were T1 or T2. The peak mucosal reactions at the larynx and/or hypopharynx were much more severe and appeared at smaller doses and earlier in AF than in CF. The patients with AF showed no severe late complications.
Conclusions: AF could not obtain statistically significant improvement in local control probability of T1 or T2 glottic carcinomas.</description><subject>Accelerated fractionation</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Dose Fractionation, Radiation</subject><subject>Female</subject><subject>Glottis - radiation effects</subject><subject>Growth fraction</subject><subject>Humans</subject><subject>Ki-67 Antigen - analysis</subject><subject>Ki-67 index</subject><subject>Laryngeal Neoplasms - chemistry</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - radiotherapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mucous Membrane - radiation effects</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Radiation therapy</subject><subject>Salvage Therapy</subject><subject>Stomatitis - etiology</subject><subject>Survival Analysis</subject><subject>T1 glottic cancer</subject><subject>T2 glottic cancer</subject><subject>Tumors</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEUhoNUdP34CUouSlFw2pPJTGbSmyJSP1DwogriTcgkZzRldrIm2dr9943uot71KifwnI_3IWSPwVcGTHz7BVxAwXN5AHAIUIEsYI1MWNvIgtf13ScyeUM2yVaMvwGAsabaIJsMmrrl0E7I_bExOGDQCS0N2jqfHvNvtqC9D_SGHdGSPgw-JWeo0cG40U_1d6pHPSyii9T3NGCcDynSZ5ce6eVFIRrqRot_d8h6r4eIu6t3m9ye_rw5OS-urs8uTo6vCsMlpEK2XclBlCIfLSXT0jYdlm3V9mWNfYXWNlybsrKt1RaF0EagzGk566rO9si3yZfl3FnwT3OMSU1dzKEGPaKfR9XktI0ElsF6CZrgYwzYq1lwUx0WioF6kapepaoXYwpAvUpVkPv2Vwvm3RTth66lxQx8XgE6Gj30QY_GxXeOl7WQVcZ-LDHMNv44DCoah6NB6wKapKx3_7nkH5r_kl4</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Sakata, Koh-ichi</creator><creator>Oouchi, Atushi</creator><creator>Nagakura, Hisayasu</creator><creator>Akiba, Hidenari</creator><creator>Tamakawa, Mistuharu</creator><creator>Koito, Kazumitsu</creator><creator>Hareyama, Masato</creator><creator>Asakura, Kohji</creator><creator>Satoh, Masaaki</creator><creator>Ohtani, Seiji</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index</title><author>Sakata, Koh-ichi ; Oouchi, Atushi ; Nagakura, Hisayasu ; Akiba, Hidenari ; Tamakawa, Mistuharu ; Koito, Kazumitsu ; Hareyama, Masato ; Asakura, Kohji ; Satoh, Masaaki ; Ohtani, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-98b230626355991a9d7be2848f25ef4edd73ac24d8dade66ac6e940931b4bdfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Accelerated fractionation</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Dose Fractionation, Radiation</topic><topic>Female</topic><topic>Glottis - radiation effects</topic><topic>Growth fraction</topic><topic>Humans</topic><topic>Ki-67 Antigen - analysis</topic><topic>Ki-67 index</topic><topic>Laryngeal Neoplasms - chemistry</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - radiotherapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mucous Membrane - radiation effects</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Radiation therapy</topic><topic>Salvage Therapy</topic><topic>Stomatitis - etiology</topic><topic>Survival Analysis</topic><topic>T1 glottic cancer</topic><topic>T2 glottic cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakata, Koh-ichi</creatorcontrib><creatorcontrib>Oouchi, Atushi</creatorcontrib><creatorcontrib>Nagakura, Hisayasu</creatorcontrib><creatorcontrib>Akiba, Hidenari</creatorcontrib><creatorcontrib>Tamakawa, Mistuharu</creatorcontrib><creatorcontrib>Koito, Kazumitsu</creatorcontrib><creatorcontrib>Hareyama, Masato</creatorcontrib><creatorcontrib>Asakura, Kohji</creatorcontrib><creatorcontrib>Satoh, Masaaki</creatorcontrib><creatorcontrib>Ohtani, Seiji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakata, Koh-ichi</au><au>Oouchi, Atushi</au><au>Nagakura, Hisayasu</au><au>Akiba, Hidenari</au><au>Tamakawa, Mistuharu</au><au>Koito, Kazumitsu</au><au>Hareyama, Masato</au><au>Asakura, Kohji</au><au>Satoh, Masaaki</au><au>Ohtani, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>47</volume><issue>1</issue><spage>81</spage><epage>88</epage><pages>81-88</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose: Hyperfractionated and accelerated radiotherapy without a split was performed to improve the local control probability of early glottic carcinomas. We analyzed the results of this regimen by using the Ki-67 index.
Methods and Materials: Over a 12-year period, 85 T1N0M0 glottic cancers and 50 T2N0M0 glottic cancers were treated with conventional fractionation (CF) from 1984 to 1989 and with accelerated fractionation (AF) since 1990. The CF program consisted of five daily fractions of 2 Gy per week, for a total of 64 Gy. The AF program consisted of 1.72 Gy per fraction, two fractions per day, 5 days a week, for a total of 55 or 58 Gy. The specimens, taken before radiotherapy, were immunohistochemically stained with anti-Ki-67 antibody.
Results: The 5-year local control probability for T1 tumors was 79.6 ± 6.9% with CF treatment, whereas with AF it was 86.9 ± 5.6%. For T2 tumors it was 62.7 ± 12.2% with CF, whereas it was 74.7 ± 7.8% with AF. The difference between CF and AF did not reach the point of statistical significance. However, when T1 tumors had a Ki-67 index lower than 50%, the local control rate achieved with AF was significantly better than that with CF (
p = 0.018). When the tumors had a Ki-67 index that was 50% or more, there was no difference in the local control rate between CF and AF, whether they were T1 or T2. The peak mucosal reactions at the larynx and/or hypopharynx were much more severe and appeared at smaller doses and earlier in AF than in CF. The patients with AF showed no severe late complications.
Conclusions: AF could not obtain statistically significant improvement in local control probability of T1 or T2 glottic carcinomas.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10758308</pmid><doi>10.1016/S0360-3016(00)00409-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Accelerated fractionation Adult Aged Aged, 80 and over Algorithms Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - radiotherapy Dose Fractionation, Radiation Female Glottis - radiation effects Growth fraction Humans Ki-67 Antigen - analysis Ki-67 index Laryngeal Neoplasms - chemistry Laryngeal Neoplasms - pathology Laryngeal Neoplasms - radiotherapy Male Medical sciences Middle Aged Mucous Membrane - radiation effects Neoplasm Staging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Radiation therapy Salvage Therapy Stomatitis - etiology Survival Analysis T1 glottic cancer T2 glottic cancer Tumors |
| title | Accelerated radiotherapy for T1, 2 glottic carcinoma: analysis of results with KI-67 index |
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