The Impact of Smoking Status, Disease Stage, and Index Tumor Site on Second Primary Tumor Incidence and Tumor Recurrence in the Head and Neck Retinoid Chemoprevention Trial

Second primary tumors (SPTs) develop at an annual rate of 3–7% in patients with head and neck squamous cell cancer (HNSCC). In a previous Phase III study, we observed that high doses of 13- cis- retinoic acid reduced the SPT rate in this disease. In 1991, we launched an intergroup, placebo-controlle...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2001-08, Vol.10 (8), p.823-829
Hauptverfasser:	Khuri, F R, Kim, E S, Lee, J J, Winn, R J, Benner, S E, Lippman, S M, Fu, K K, Cooper, J S, Vokes, E E, Chamberlain, R M, Williams, B, Pajak, T F, Goepfert, H, Hong, W K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Chemoprevention Cotinine - blood Dermatologic Agents - pharmacology Double-Blind Method Female Head and Neck Neoplasms - epidemiology Head and Neck Neoplasms - etiology Head and Neck Neoplasms - prevention & control Humans Incidence Isotretinoin - pharmacology Male Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - etiology Neoplasms, Second Primary - prevention & control Smoking - adverse effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!