Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide

We report here on our medicinal chemistry and pharmacology efforts to provide a potent sorbitol dehydrogenase inhibitor (SDI) as a tool to probe a recently disclosed hypothesis centered on the role of sorbitol dehydrogenase (SDH) in the second step of the polyol pathway, under conditions of high glu...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-08, Vol.44 (17), p.2695-2700
Hauptverfasser:	Mylari, Banavara L, Oates, Peter J, Beebe, David A, Brackett, Nathaniel S, Coutcher, James B, Dina, Michael S, Zembrowski, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Diabetes Mellitus, Experimental - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Fructose - antagonists & inhibitors Fructose - biosynthesis General and cellular metabolism. Vitamins Humans L-Iditol 2-Dehydrogenase - antagonists & inhibitors Medical sciences Pharmacology. Drug treatments Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacokinetics Pyrimidines - pharmacology Rats Sciatic Nerve - metabolism Stereoisomerism Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacokinetics Sulfonamides - pharmacology Tissue Distribution
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