A mouse model of Streptococcus pneumoniae meningitis mimicking several features of human disease

The course of bacterial titers, meningeal inflammation, behavioral abnormalities, and neuronal damage was studied in a mouse model of Streptococcus pneumoniae meningitis. At 24 h after injection of 10(4) colony-forming units (CFU) S. pneumoniae into the right forebrain, infected mice became severely...

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Veröffentlicht in:	Acta neuropathologica 2001-05, Vol.101 (5), p.499-508
Hauptverfasser:	GERBER, J, RAIVICH, G, WELLMER, A, NOESKE, C, KUNST, T, WERNER, A, BRÜCK, W, NAU, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Biological and medical sciences Body Weight - immunology Brain - immunology Brain - microbiology Brain - pathology Ceftriaxone Ceftriaxone - pharmacology Cell adhesion & migration Cell adhesion molecules Cephalosporins - pharmacology Cerebellum Cerebrospinal fluid Colonies Colony-stimulating factor Disease Models, Animal Forebrain Glial Fibrillary Acidic Protein - metabolism Gliosis - immunology Gliosis - microbiology Gliosis - pathology Hippocampus Human bacterial diseases Hyaluronan Receptors - metabolism Immunohistochemistry Infectious diseases Inflammation Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Leukocyte Count Leukocytes (granulocytic) Leukocytes - immunology Leukocytes - microbiology Leukocytes - pathology Macrophage colony-stimulating factor Macrophage Colony-Stimulating Factor - deficiency Macrophage Colony-Stimulating Factor - genetics Macrophage-1 Antigen - metabolism Medical sciences Meninges Meningitis Meningitis, Pneumococcal - drug therapy Meningitis, Pneumococcal - pathology Meningitis, Pneumococcal - physiopathology Mice Mice, Inbred C57BL Mice, Knockout Mimicry Neocortex Neostriatum Rodents Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - pathogenicity Streptococcus pneumoniae - physiology Survival Rate Treatment Outcome
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