IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6

The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6. Although the function of these viral proteins is unclear, they might have the potential to modulate the immune system. For...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-05, Vol.164 (9), p.4672-4677
Hauptverfasser:	Mullberg, Jurgen, Geib, Till, Jostock, Thomas, Hoischen, Susanne H, Vollmer, Petra, Voltz, Nicole, Heinz, David, Galle, Peter R, Klouche, Mariam, Rose-John, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antigens, CD - biosynthesis Antigens, CD - metabolism Chemical Precipitation Cloning, Molecular COS Cells Cytokine Receptor gp130 DNA-Binding Proteins - metabolism Genetic Vectors glycoprotein gp130 Growth Inhibitors - pharmacology Human herpesvirus 8 Humans Interleukin 6 receptors Interleukin-6 - genetics Interleukin-6 - metabolism Interleukin-6 - physiology Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - metabolism Phosphorylation Protein Binding Receptors, Interleukin-6 - metabolism Receptors, Interleukin-6 - physiology Recombinant Proteins - isolation & purification Recombinant Proteins - pharmacology Sarcoma, Kaposi - chemistry Sarcoma, Kaposi - immunology Sarcoma, Kaposi - pathology Signal Transduction - immunology STAT3 Transcription Factor Trans-Activators - metabolism Tumor Cells, Cultured Viral Proteins - genetics Viral Proteins - metabolism Viral Proteins - physiology
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