Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon

In the caudal neural tube, oligodendrocyte progenitors (OLPs) originate in the ventral neuroepithelium under the influence of Sonic hedgehog (SHH), then migrate throughout the spinal cord and brainstem before differentiating into myelin-forming cells. We present evidence that oligodendrogenesis in t...

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Veröffentlicht in:	Development (Cambridge) 2001-07, Vol.128 (13), p.2545-2554
Hauptverfasser:	Tekki-Kessaris, N, Woodruff, R, Hall, A C, Gaffield, W, Kimura, S, Stiles, C D, Rowitch, D H, Richardson, W D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors Cell Differentiation Cell Lineage Cells, Cultured Cerebral Cortex - metabolism Cerebral Cortex - pathology cyclopamine DNA-Binding Proteins - genetics Gene Expression Genes, Overlapping Hedgehog gene Hedgehog Proteins High Mobility Group Proteins - genetics Indian hedgehog protein Intracellular Signaling Peptides and Proteins Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Knockout Nerve Tissue Proteins - genetics Nkx2.1 gene OLIG1 protein OLIG2 protein Oligodendrocyte Transcription Factor 2 Oligodendroglia - cytology Patched Receptors Patched-1 Receptor Prosencephalon - metabolism Prosencephalon - pathology Proteins - genetics Proteins - metabolism Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor alpha - genetics Receptors, Cell Surface Shh gene Sonic hedgehog gene Sonic hedgehog protein Sox10 protein SOXE Transcription Factors Stem Cells - cytology Telencephalon - cytology Telencephalon - metabolism Trans-Activators Transcription Factors
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