Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins

Hematopoietic stem cells are derived from ventral mesoderm during vertebrate development. Gene targeting experiments in the mouse have demonstrated key roles for the basic helix-loop-helix transcription factor SCL and the GATA-binding protein GATA-1 in hematopoiesis. When overexpressed in Xenopus an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Development (Cambridge) 2001-06, Vol.128 (12), p.2301-2308
Hauptverfasser:	Mead, P E, Deconinck, A E, Huber, T L, Orkin, S H, Zon, L I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Basic Helix-Loop-Helix Transcription Factors Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins - genetics Cloning, Molecular DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Erythroid-Specific DNA-Binding Factors Erythropoiesis - physiology Freshwater GATA-1 protein GATA1 Transcription Factor Gene Expression Globins - genetics Helix-Loop-Helix Motifs Humans LIM Domain Proteins LMO-2 protein Metalloproteins - genetics Metalloproteins - physiology Mice Molecular Sequence Data Proto-Oncogene Proteins SCL protein Smad Proteins T-Cell Acute Lymphocytic Leukemia Protein 1 Trans-Activators - genetics Transcription Factors - genetics Transcription Factors - physiology Xenopus Xenopus laevis - embryology Xenopus Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!