Total Synthesis of Ningalin B Utilizing a Heterocyclic Azadiene Diels−Alder Reaction and Discovery of a New Class of Potent Multidrug Resistant (MDR) Reversal Agents

A concise, efficient approach to the total synthesis of ningalin B (1) based on a heterocyclic azadiene Diels−Alder strategy (1,2,4,5-tetrazine → 1,2-diazine → pyrrole) ideally suited for construction of the densely functionalized pyrrole core found in the natural product is detailed. Examination of...

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Veröffentlicht in:	Journal of organic chemistry 2000-04, Vol.65 (8), p.2479-2483
Hauptverfasser:	Boger, Dale L, Soenen, Danielle R, Boyce, Christopher W, Hedrick, Michael P, Jin, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents - chemical synthesis Cell Survival - drug effects Doxorubicin - pharmacology Drug Resistance, Multiple Drug Resistance, Neoplasm Heterocyclic Compounds, 3-Ring - chemical synthesis Humans Mice Tumor Cells, Cultured Urochordata - chemistry
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