A novel polymorphism in the 5' promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels

Interleukin (IL)-4 exerts its biological effects through binding to the IL-4 receptor (IL4R) complex, plays a central role in stimulating B-cell differentiation, and is crucial for the development of T helper 2 cells. Recently, a soluble form of the human IL4R alpha chain (sIL4R alpha), which is pro...

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Veröffentlicht in:	Immunogenetics (New York) 2001-05, Vol.53 (4), p.264-269
Hauptverfasser:	Hackstein, H, Hecker, M, Kruse, S, Bohnert, A, Ober, C, Deichmann, K A, Bein, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Frequency Genetic Variation Genotype Humans IL4RA gene interleukin 4 receptors Linkage Disequilibrium Molecular Sequence Data Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide Promoter Regions, Genetic - genetics Receptors, Interleukin-4 - genetics Receptors, Interleukin-4 - isolation & purification Sequence Analysis, DNA Signal Transduction Solubility
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