Gene transfer-mediated intracellular photodynamic therapy
The main limitation of photodynamic therapy is a very short penetrance length of the light in tissues. To overcome this shortcoming, a new method is proposed, where first a gene encoding protein luciferase is delivered using, e.g. adenovirus vector to the neoplastic cells and, after its expression,...
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| Veröffentlicht in: | Medical hypotheses 2000-02, Vol.54 (2), p.180-181 |
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| container_end_page | 181 |
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| container_title | Medical hypotheses |
| container_volume | 54 |
| creator | Babincová, M. Sourivong, P. Babinec, P. |
| description | The main limitation of photodynamic therapy is a very short penetrance length of the light in tissues. To overcome this shortcoming, a new method is proposed, where first a gene encoding protein luciferase is delivered using, e.g. adenovirus vector to the neoplastic cells and, after its expression, the photosensitizer, which should be activated, together with luciferin are injected to the organism. After their accumulation in the cancer cells, the photosensitizer activation is accomplished via light produced by chemiluminiscent reaction of luciferase and luciferin. |
| doi_str_mv | 10.1054/mehy.1999.0012 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 2000-02, Vol.54 (2), p.180-181 |
| issn | 0306-9877 1532-2777 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71075526 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Brain Neoplasms - therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Medical sciences Neoplasms - therapy Photochemotherapy - methods Photoradiation therapy and photosensitizing agent Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors |
| title | Gene transfer-mediated intracellular photodynamic therapy |
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