Nerve regeneration through an epineurial sheath: Its functional aspect compared with nerve and vein grafts

Although nerve graft is still the only reliable choice in repair of defects in peripheral nerve structure, it has the disadvantage of donor nerve morbidity and of sometimes being unavailable. It has long been researched in alternate nerve grafts with other materials. Studies have shown that nerves c...

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Veröffentlicht in:Microsurgery 2001, Vol.21 (5), p.196-201
Hauptverfasser: Karacaoğlu, Ercan, Yüksel, Fuat, Peker, Fatih, Güler, M. Mümtaz
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Yüksel, Fuat
Peker, Fatih
Güler, M. Mümtaz
description Although nerve graft is still the only reliable choice in repair of defects in peripheral nerve structure, it has the disadvantage of donor nerve morbidity and of sometimes being unavailable. It has long been researched in alternate nerve grafts with other materials. Studies have shown that nerves could regenerate across short nerve gaps through various conduits, such as veins, pseudosheaths, and bioabsorbable tubes. Despite encouraging studies, their functional results remain unclear. The present study used 40 rats, in which nerve grafts, vein grafts, and epineurial tubes were placed into 1‐cm gaps in sciatic nerves created by resection. In one group, sciatic nerves were denuded of the surrounding epineurium, to assess the possible morbidity caused by epineurial sheath technique. At 2, 4, 8, 12, 20, and 28 weeks, functional assessment of nerve regeneration was performed using walking track analysis. The number of myelinated fibers and fiber diameters was measured and electron microscopic evaluation performed. Functionally, the index values were very close to each other in nerve graft and epineurial sheath groups. Morphometric analysis showed significance between the groups. The result of denuded sciatic nerve group was the same as the base track values. It was concluded that the ready availability of epineurial sheath as a conduit to span short nerve gaps could eliminate the morbidity associated with nerve graft harvest and capitalize on the potential benefits of neurotrophism in directing nerve regeneration. © 2001 Wiley‐Liss, Inc. Microsurgery 21:196–201 2001
doi_str_mv 10.1002/micr.1038
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At 2, 4, 8, 12, 20, and 28 weeks, functional assessment of nerve regeneration was performed using walking track analysis. The number of myelinated fibers and fiber diameters was measured and electron microscopic evaluation performed. Functionally, the index values were very close to each other in nerve graft and epineurial sheath groups. Morphometric analysis showed significance between the groups. The result of denuded sciatic nerve group was the same as the base track values. It was concluded that the ready availability of epineurial sheath as a conduit to span short nerve gaps could eliminate the morbidity associated with nerve graft harvest and capitalize on the potential benefits of neurotrophism in directing nerve regeneration. © 2001 Wiley‐Liss, Inc. 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In one group, sciatic nerves were denuded of the surrounding epineurium, to assess the possible morbidity caused by epineurial sheath technique. At 2, 4, 8, 12, 20, and 28 weeks, functional assessment of nerve regeneration was performed using walking track analysis. The number of myelinated fibers and fiber diameters was measured and electron microscopic evaluation performed. Functionally, the index values were very close to each other in nerve graft and epineurial sheath groups. Morphometric analysis showed significance between the groups. The result of denuded sciatic nerve group was the same as the base track values. It was concluded that the ready availability of epineurial sheath as a conduit to span short nerve gaps could eliminate the morbidity associated with nerve graft harvest and capitalize on the potential benefits of neurotrophism in directing nerve regeneration. © 2001 Wiley‐Liss, Inc. 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Psychology</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Jugular Veins - physiology</subject><subject>Jugular Veins - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsurgery - methods</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurosurgery</subject><subject>Peripheral Nerves - transplantation</subject><subject>Probability</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sciatic Nerve - physiology</subject><subject>Sciatic Nerve - surgery</subject><subject>Sensitivity and Specificity</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Autonomic nervous system</topic><topic>Degeneration. Regeneration. Wound healing. Graft</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Jugular Veins - physiology</topic><topic>Jugular Veins - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsurgery - methods</topic><topic>Nerve Regeneration - physiology</topic><topic>Neurosurgery</topic><topic>Peripheral Nerves - transplantation</topic><topic>Probability</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sciatic Nerve - physiology</topic><topic>Sciatic Nerve - surgery</topic><topic>Sensitivity and Specificity</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. 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subjects Animals
Biological and medical sciences
Cranial nerves. Peripheral nerves. Autonomic nervous system
Degeneration. Regeneration. Wound healing. Graft
Disease Models, Animal
Female
Fundamental and applied biological sciences. Psychology
Graft Rejection
Graft Survival
Jugular Veins - physiology
Jugular Veins - surgery
Male
Medical sciences
Microsurgery - methods
Nerve Regeneration - physiology
Neurosurgery
Peripheral Nerves - transplantation
Probability
Rats
Rats, Sprague-Dawley
Sciatic Nerve - physiology
Sciatic Nerve - surgery
Sensitivity and Specificity
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue Transplantation - methods
Tropical medicine
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Nerve regeneration through an epineurial sheath: Its functional aspect compared with nerve and vein grafts
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