IGF and insulin action in the mammary gland: lessons from transgenic and knockout models
Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. This review focuses on...
Gespeichert in:
| Veröffentlicht in: | Journal of mammary gland biology and neoplasia 2000-01, Vol.5 (1), p.19-30 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 30 |
|---|---|
| container_issue | 1 |
| container_start_page | 19 |
| container_title | Journal of mammary gland biology and neoplasia |
| container_volume | 5 |
| creator | Hadsell, D L Bonnette, S G |
| description | Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. This review focuses on results obtained from the application of transgenic and knockout models to determine the roles of insulin and insulin-like growth factors (IGF) in the regulation of mammary gland development, lactation and tumorigenesis. Transgenic models which overexpress IGF-I or -II display specific alterations in mammary gland development and an increased incidence of mammary tumors. Analysis of mammary gland development in knockout mice which are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF system is important for normal mammary gland development. This review discusses these observations in detail and attempts to fit them into a larger picture of IGF and insulin action in the mammary gland. |
| doi_str_mv | 10.1023/A:1009559014703 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_71074844</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71074844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c280t-d725a0650b89b753383cce73be3947036374f7292cc4c3fd78c230bfaf9121103</originalsourceid><addsrcrecordid>eNpdkDFPwzAUhC0EolCY2ZDFwBZ49ovjuBuqKFSqxAISW-Q4Tkmb2CVOBv49LpSF6d2TPp3ujpArBncMON4_zBiAEkIBSyXgETljQmISpTqOGnJMEDibkPMQNhDRPBOnZMJAKiYzcUbel08Lql1FGxfGtnFUm6HxLr50-LC0012n-y-6biMzo60NwbtA6953dOi1C2vrGvNjsHXebP040M5Xtg0X5KTWbbCXhzslb4vH1_lzsnp5Ws4fVonhOQxJJbnQkAkoc1VKgZijMVZiaVHtG2Uo01pyxY1JDdaVzA1HKGtdK8YZA5yS21_fXe8_RxuGomuCsW0MbP0YChm7pnmaRvDmH7jxY-9itoIzxTKFca0puT5AY9nZqtj1zb5_8TcYfgNQFGtQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219169308</pqid></control><display><type>article</type><title>IGF and insulin action in the mammary gland: lessons from transgenic and knockout models</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Hadsell, D L ; Bonnette, S G</creator><creatorcontrib>Hadsell, D L ; Bonnette, S G</creatorcontrib><description>Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. This review focuses on results obtained from the application of transgenic and knockout models to determine the roles of insulin and insulin-like growth factors (IGF) in the regulation of mammary gland development, lactation and tumorigenesis. Transgenic models which overexpress IGF-I or -II display specific alterations in mammary gland development and an increased incidence of mammary tumors. Analysis of mammary gland development in knockout mice which are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF system is important for normal mammary gland development. This review discusses these observations in detail and attempts to fit them into a larger picture of IGF and insulin action in the mammary gland.</description><identifier>ISSN: 1083-3021</identifier><identifier>EISSN: 1573-7039</identifier><identifier>DOI: 10.1023/A:1009559014703</identifier><identifier>PMID: 10791765</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Breast - physiology ; Breast Neoplasms - physiopathology ; Female ; Humans ; Insulin-Like Growth Factor I - physiology ; Insulin-Like Growth Factor II - physiology ; Mammary Glands, Animal - physiology ; Mammary Neoplasms, Animal - physiopathology ; Mice ; Mice, Knockout ; Mice, Transgenic</subject><ispartof>Journal of mammary gland biology and neoplasia, 2000-01, Vol.5 (1), p.19-30</ispartof><rights>Copyright Kluwer Academic Publishers Jan 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-d725a0650b89b753383cce73be3947036374f7292cc4c3fd78c230bfaf9121103</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10791765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hadsell, D L</creatorcontrib><creatorcontrib>Bonnette, S G</creatorcontrib><title>IGF and insulin action in the mammary gland: lessons from transgenic and knockout models</title><title>Journal of mammary gland biology and neoplasia</title><addtitle>J Mammary Gland Biol Neoplasia</addtitle><description>Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. This review focuses on results obtained from the application of transgenic and knockout models to determine the roles of insulin and insulin-like growth factors (IGF) in the regulation of mammary gland development, lactation and tumorigenesis. Transgenic models which overexpress IGF-I or -II display specific alterations in mammary gland development and an increased incidence of mammary tumors. Analysis of mammary gland development in knockout mice which are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF system is important for normal mammary gland development. This review discusses these observations in detail and attempts to fit them into a larger picture of IGF and insulin action in the mammary gland.</description><subject>Animals</subject><subject>Breast - physiology</subject><subject>Breast Neoplasms - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Insulin-Like Growth Factor II - physiology</subject><subject>Mammary Glands, Animal - physiology</subject><subject>Mammary Neoplasms, Animal - physiopathology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><issn>1083-3021</issn><issn>1573-7039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkDFPwzAUhC0EolCY2ZDFwBZ49ovjuBuqKFSqxAISW-Q4Tkmb2CVOBv49LpSF6d2TPp3ujpArBncMON4_zBiAEkIBSyXgETljQmISpTqOGnJMEDibkPMQNhDRPBOnZMJAKiYzcUbel08Lql1FGxfGtnFUm6HxLr50-LC0012n-y-6biMzo60NwbtA6953dOi1C2vrGvNjsHXebP040M5Xtg0X5KTWbbCXhzslb4vH1_lzsnp5Ws4fVonhOQxJJbnQkAkoc1VKgZijMVZiaVHtG2Uo01pyxY1JDdaVzA1HKGtdK8YZA5yS21_fXe8_RxuGomuCsW0MbP0YChm7pnmaRvDmH7jxY-9itoIzxTKFca0puT5AY9nZqtj1zb5_8TcYfgNQFGtQ</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Hadsell, D L</creator><creator>Bonnette, S G</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>IGF and insulin action in the mammary gland: lessons from transgenic and knockout models</title><author>Hadsell, D L ; Bonnette, S G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-d725a0650b89b753383cce73be3947036374f7292cc4c3fd78c230bfaf9121103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Breast - physiology</topic><topic>Breast Neoplasms - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Insulin-Like Growth Factor II - physiology</topic><topic>Mammary Glands, Animal - physiology</topic><topic>Mammary Neoplasms, Animal - physiopathology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mice, Transgenic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hadsell, D L</creatorcontrib><creatorcontrib>Bonnette, S G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mammary gland biology and neoplasia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hadsell, D L</au><au>Bonnette, S G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IGF and insulin action in the mammary gland: lessons from transgenic and knockout models</atitle><jtitle>Journal of mammary gland biology and neoplasia</jtitle><addtitle>J Mammary Gland Biol Neoplasia</addtitle><date>2000-01</date><risdate>2000</risdate><volume>5</volume><issue>1</issue><spage>19</spage><epage>30</epage><pages>19-30</pages><issn>1083-3021</issn><eissn>1573-7039</eissn><abstract>Transgenic and knockout mice have become valuable experimental systems with which to study specific molecular events within the mammary gland of an intact animal. These models have provided a wealth of information about the effects of a number of oncogenes and growth factors. This review focuses on results obtained from the application of transgenic and knockout models to determine the roles of insulin and insulin-like growth factors (IGF) in the regulation of mammary gland development, lactation and tumorigenesis. Transgenic models which overexpress IGF-I or -II display specific alterations in mammary gland development and an increased incidence of mammary tumors. Analysis of mammary gland development in knockout mice which are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF system is important for normal mammary gland development. This review discusses these observations in detail and attempts to fit them into a larger picture of IGF and insulin action in the mammary gland.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>10791765</pmid><doi>10.1023/A:1009559014703</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-3021 |
| ispartof | Journal of mammary gland biology and neoplasia, 2000-01, Vol.5 (1), p.19-30 |
| issn | 1083-3021 1573-7039 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71074844 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Breast - physiology Breast Neoplasms - physiopathology Female Humans Insulin-Like Growth Factor I - physiology Insulin-Like Growth Factor II - physiology Mammary Glands, Animal - physiology Mammary Neoplasms, Animal - physiopathology Mice Mice, Knockout Mice, Transgenic |
| title | IGF and insulin action in the mammary gland: lessons from transgenic and knockout models |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A54%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IGF%20and%20insulin%20action%20in%20the%20mammary%20gland:%20lessons%20from%20transgenic%20and%20knockout%20models&rft.jtitle=Journal%20of%20mammary%20gland%20biology%20and%20neoplasia&rft.au=Hadsell,%20D%20L&rft.date=2000-01&rft.volume=5&rft.issue=1&rft.spage=19&rft.epage=30&rft.pages=19-30&rft.issn=1083-3021&rft.eissn=1573-7039&rft_id=info:doi/10.1023/A:1009559014703&rft_dat=%3Cproquest_pubme%3E71074844%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219169308&rft_id=info:pmid/10791765&rfr_iscdi=true |