Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats
The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 2001, Vol.86(3), pp.366-368 |
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| container_end_page | 368 |
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| container_title | Japanese Journal of Pharmacology |
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| creator | Sutoo, Den’etsu Akiyama, Kayo |
| description | The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain. |
| doi_str_mv | 10.1254/jjp.86.366 |
| format | Article |
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The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.86.366</identifier><identifier>PMID: 11488441</identifier><language>eng</language><publisher>Japan: The Japanese Pharmacological Society</publisher><subject>Animals ; Blood Pressure - drug effects ; Blood pressure in spontaneously hypertensive rats ; Calcium - administration & dosage ; Calcium - pharmacology ; Calcium/calmodulin-dependent dopamine synthesis ; Injections, Intraventricular ; Magnesium ; Magnesium - administration & dosage ; Magnesium - pharmacology ; Male ; Rats ; Rats, Inbred SHR</subject><ispartof>The Japanese Journal of Pharmacology, 2001, Vol.86(3), pp.366-368</ispartof><rights>2001 Elsevier B.V.</rights><rights>The Japanese Pharmacological Society 2001</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c699t-9b35d95653a74bde32f47820015fdefb135cf77f4fb3582379604190ff78a6d83</citedby><cites>FETCH-LOGICAL-c699t-9b35d95653a74bde32f47820015fdefb135cf77f4fb3582379604190ff78a6d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11488441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sutoo, Den’etsu</creatorcontrib><creatorcontrib>Akiyama, Kayo</creatorcontrib><creatorcontrib>Institute of Medical Science</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><title>Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats</title><title>Japanese Journal of Pharmacology</title><addtitle>Jpn.J.Pharmacol.</addtitle><description>The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Blood pressure in spontaneously hypertensive rats</subject><subject>Calcium - administration & dosage</subject><subject>Calcium - pharmacology</subject><subject>Calcium/calmodulin-dependent dopamine synthesis</subject><subject>Injections, Intraventricular</subject><subject>Magnesium</subject><subject>Magnesium - administration & dosage</subject><subject>Magnesium - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUuPFCEUhYnROG3rxh9gWLkw6RYaiqJWRjvzMBkzxsea0NSlhwoNJVCT9L-XTvWMGzeX3NyPwz0HhN5Ssqabhn8chnEtxZoJ8QwtKOPtijVEPEcLQjZ01dBOXqBXOQ-1lYTyl-iCUi4l53SBjnfjGLMrgC-tBVMyjhZvtTduOmAdevxN7wPkUxcDLveAtxBK0h5_8TH2-HuCnKcE-AfsJ6-Lq5SbwZ9jDEUHiFP2R3xzHCEVCNk9VFiX_Bq9sNpneHM-l-j31eWv7c3q9u766_bz7cqIriurbseavmtEw3TLdz2wjeWt3BBCG9uD3VHWGNu2ltsKyg1rO0E47Yi1rdSil2yJ3s-6Y4p_JshFHVw24P28mmopabnkrIIfZtCkmHMCq8bkDjodFSXqFLSqQSspVA26wu_OqtPuAP0_9JxsBa5moE6d0T4G7wKoIU4pVLvKWDEMcfTqZEURIgVhitBWkSp_KlJ2jFTbS_RpFhpy0Xt4ekmn4oyHp6Xmcrr8ODH3OikIVYHPClBjfnCQVDYOgqmLpfrlqo_ufxb_ApAvuY0</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Sutoo, Den’etsu</creator><creator>Akiyama, Kayo</creator><general>The Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats</title><author>Sutoo, Den’etsu ; Akiyama, Kayo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c699t-9b35d95653a74bde32f47820015fdefb135cf77f4fb3582379604190ff78a6d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Blood pressure in spontaneously hypertensive rats</topic><topic>Calcium - administration & dosage</topic><topic>Calcium - pharmacology</topic><topic>Calcium/calmodulin-dependent dopamine synthesis</topic><topic>Injections, Intraventricular</topic><topic>Magnesium</topic><topic>Magnesium - administration & dosage</topic><topic>Magnesium - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><toplevel>online_resources</toplevel><creatorcontrib>Sutoo, Den’etsu</creatorcontrib><creatorcontrib>Akiyama, Kayo</creatorcontrib><creatorcontrib>Institute of Medical Science</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sutoo, Den’etsu</au><au>Akiyama, Kayo</au><aucorp>Institute of Medical Science</aucorp><aucorp>University of Tsukuba</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats</atitle><jtitle>Japanese Journal of Pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>2001</date><risdate>2001</risdate><volume>86</volume><issue>3</issue><spage>366</spage><epage>368</epage><pages>366-368</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><abstract>The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 μg/rat) and increased by magnesium chloride (20, 100 or 500 μg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.</abstract><cop>Japan</cop><pub>The Japanese Pharmacological Society</pub><pmid>11488441</pmid><doi>10.1254/jjp.86.366</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Japanese Journal of Pharmacology, 2001, Vol.86(3), pp.366-368 |
| issn | 0021-5198 1347-3506 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Blood Pressure - drug effects Blood pressure in spontaneously hypertensive rats Calcium - administration & dosage Calcium - pharmacology Calcium/calmodulin-dependent dopamine synthesis Injections, Intraventricular Magnesium Magnesium - administration & dosage Magnesium - pharmacology Male Rats Rats, Inbred SHR |
| title | Opposite Effects of Calcium and Magnesium on the Central Blood Pressure Regulation in the Spontaneously Hypertensive Rats |
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