Liver Stem Cells: A Potential Source of Hepatocytes for the Treatment of Human Liver Disease
: Severe liver injury often leads to the proliferation of oval cells, which differentiate along hepatocytic and biliary lineages. Because oval cells proliferate only when hepatocyte replication is impaired, they are considered to be the progeny of facultative liver stem cells (FLSCs). Identification...
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| Veröffentlicht in: | Artificial organs 2001-07, Vol.25 (7), p.513-521 |
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| creator | Faris, Ronald A. Konkin, Tamako Halpert, Gretchen |
| description | : Severe liver injury often leads to the proliferation of oval cells, which differentiate along hepatocytic and biliary lineages. Because oval cells proliferate only when hepatocyte replication is impaired, they are considered to be the progeny of facultative liver stem cells (FLSCs). Identification and isolation of FLSCs has been hampered by the lack of markers that delineate these bipotential progenitors. We hypothesized that transition ductal cells are FLSCs because they are located in a unique anatomical niche sharing tight junctions with a neighboring hepatocyte and another terminal ductular cell. Alternatively, it has been proposed recently that bone marrow‐derived stem cells are FLSCs since these cells differentiate along the hepatic lineage following colonization of the liver. The intent of this review is to provide insight into the nature and origin of liver stem cells and to explore the possibility that stem cell technology may lead to the development of clinical modalities for the treatment of human liver disease. |
| doi_str_mv | 10.1046/j.1525-1594.2001.025007513.x |
| format | Article |
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Because oval cells proliferate only when hepatocyte replication is impaired, they are considered to be the progeny of facultative liver stem cells (FLSCs). Identification and isolation of FLSCs has been hampered by the lack of markers that delineate these bipotential progenitors. We hypothesized that transition ductal cells are FLSCs because they are located in a unique anatomical niche sharing tight junctions with a neighboring hepatocyte and another terminal ductular cell. Alternatively, it has been proposed recently that bone marrow‐derived stem cells are FLSCs since these cells differentiate along the hepatic lineage following colonization of the liver. The intent of this review is to provide insight into the nature and origin of liver stem cells and to explore the possibility that stem cell technology may lead to the development of clinical modalities for the treatment of human liver disease.</description><subject>Adult</subject><subject>Animals</subject><subject>Bone marrow</subject><subject>Cell Division - physiology</subject><subject>Cell Transplantation - methods</subject><subject>Differentiation</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Hepatocytes - transplantation</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - cytology</subject><subject>Liver failure</subject><subject>Liver Failure - therapy</subject><subject>Rats</subject><subject>Sensitivity and Specificity</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells</subject><subject>Stem Cells - physiology</subject><subject>Transition duct cells</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV1P2zAUhi0EgsL2FyZfIO6S-Tsp2k1VRplU0YoiwcUky3VPtHRJ09kOtP9-zlJ11_jGlvyc9_g8RuiakpQSob6uUyqZTKgcipQRQlPCJCGZpDzdnaDB8fIUDQhVJJFKvF6gS-_XJGKCqHN0QakYcpbRAfo5Ld_A4UWAGo-hqvwtHuF5E2ATSlPhRdM6C7gp8ANsTWjsPoDHReNw-AX42YEJdUT_AW1tNriPuys9GA-f0FlhKg-fD_sVWtx_fx4_JNPZ5Md4NE2siCtRuRpaka-KJeOUKyOsXOW5FBxgxa1cyhwYi0epDDdKKAGZya2gmRJSMX6FbvrUrWv-tOCDrktv4yxmA03rdUbj2IKICH7rQesa7x0UeuvK2ri9pkR3bvVad_p0p093bvXRrd7F8i-HPu2yhtX_4oPMCIx64L2sYP-hcD2aPamcdW9M-ozSB9gdM4z7rVXGM6lfHif6JX7p5HU-0Xf8Lyoclu8</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Faris, Ronald A.</creator><creator>Konkin, Tamako</creator><creator>Halpert, Gretchen</creator><general>Blackwell Science Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>Liver Stem Cells: A Potential Source of Hepatocytes for the Treatment of Human Liver Disease</title><author>Faris, Ronald A. ; Konkin, Tamako ; Halpert, Gretchen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4444-6869c48dfb23136a4c5d88543eed3c5b58e22ed356a3a6464e7a8c417645623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Bone marrow</topic><topic>Cell Division - physiology</topic><topic>Cell Transplantation - methods</topic><topic>Differentiation</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Hepatocytes - transplantation</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - cytology</topic><topic>Liver failure</topic><topic>Liver Failure - therapy</topic><topic>Rats</topic><topic>Sensitivity and Specificity</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells</topic><topic>Stem Cells - physiology</topic><topic>Transition duct cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faris, Ronald A.</creatorcontrib><creatorcontrib>Konkin, Tamako</creatorcontrib><creatorcontrib>Halpert, Gretchen</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faris, Ronald A.</au><au>Konkin, Tamako</au><au>Halpert, Gretchen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver Stem Cells: A Potential Source of Hepatocytes for the Treatment of Human Liver Disease</atitle><jtitle>Artificial organs</jtitle><addtitle>Artificial Organs</addtitle><date>2001-07</date><risdate>2001</risdate><volume>25</volume><issue>7</issue><spage>513</spage><epage>521</epage><pages>513-521</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>: Severe liver injury often leads to the proliferation of oval cells, which differentiate along hepatocytic and biliary lineages. 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The intent of this review is to provide insight into the nature and origin of liver stem cells and to explore the possibility that stem cell technology may lead to the development of clinical modalities for the treatment of human liver disease.</abstract><cop>Boston, MA, USA</cop><pub>Blackwell Science Inc</pub><pmid>11493271</pmid><doi>10.1046/j.1525-1594.2001.025007513.x</doi><tpages>9</tpages></addata></record> |
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| ispartof | Artificial organs, 2001-07, Vol.25 (7), p.513-521 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Animals Bone marrow Cell Division - physiology Cell Transplantation - methods Differentiation Graft Rejection Graft Survival Hepatocytes - transplantation Humans Liver Liver - cytology Liver failure Liver Failure - therapy Rats Sensitivity and Specificity Stem Cell Transplantation Stem cells Stem Cells - physiology Transition duct cells |
| title | Liver Stem Cells: A Potential Source of Hepatocytes for the Treatment of Human Liver Disease |
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