Efavirenz in HIV Infection
To the Editor: Staszewski et al. (Dec. 16 issue) 1 report that “the combination of efavirenz, zidovudine, and lamivudine has greater antiviral activity . . . than the combination of indinavir, zidovudine, and lamivudine.” However, their conclusions may have been overstated. Open-label studies such a...
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| Veröffentlicht in: | The New England journal of medicine 2000-04, Vol.342 (17), p.1290-1291 |
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| container_title | The New England journal of medicine |
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| creator | Casado, J L Moreno, S |
| description | To the Editor:
Staszewski et al. (Dec. 16 issue)
1
report that “the combination of efavirenz, zidovudine, and lamivudine has greater antiviral activity . . . than the combination of indinavir, zidovudine, and lamivudine.” However, their conclusions may have been overstated. Open-label studies such as theirs are less expensive, are easier to perform, and require fewer pills than randomized studies, but the design may not be adequate to compare two very different treatments, in terms of both the number of pills and the dosage (four pills of indinavir taken three times daily without food and three pills of efavirenz taken once . . . |
| doi_str_mv | 10.1056/NEJM200004273421713 |
| format | Article |
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Staszewski et al. (Dec. 16 issue)
1
report that “the combination of efavirenz, zidovudine, and lamivudine has greater antiviral activity . . . than the combination of indinavir, zidovudine, and lamivudine.” However, their conclusions may have been overstated. Open-label studies such as theirs are less expensive, are easier to perform, and require fewer pills than randomized studies, but the design may not be adequate to compare two very different treatments, in terms of both the number of pills and the dosage (four pills of indinavir taken three times daily without food and three pills of efavirenz taken once . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200004273421713</identifier><identifier>PMID: 10787332</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>AIDS/HIV ; Benzoxazines ; Drug Therapy, Combination ; HIV Infections - drug therapy ; HIV Protease Inhibitors - therapeutic use ; Humans ; Indinavir - therapeutic use ; Lamivudine - therapeutic use ; Oxazines - therapeutic use ; Research Design ; Reverse Transcriptase Inhibitors - therapeutic use ; RNA, Viral - blood ; Viral Load ; Zidovudine - therapeutic use</subject><ispartof>The New England journal of medicine, 2000-04, Vol.342 (17), p.1290-1291</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c353t-ac7170112a0e1acf2207126923b16c6513c32db4db7a24130bf4cc2fc6d617493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200004273421713$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200004273421713$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10787332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casado, J L</creatorcontrib><creatorcontrib>Moreno, S</creatorcontrib><title>Efavirenz in HIV Infection</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Staszewski et al. (Dec. 16 issue)
1
report that “the combination of efavirenz, zidovudine, and lamivudine has greater antiviral activity . . . than the combination of indinavir, zidovudine, and lamivudine.” However, their conclusions may have been overstated. Open-label studies such as theirs are less expensive, are easier to perform, and require fewer pills than randomized studies, but the design may not be adequate to compare two very different treatments, in terms of both the number of pills and the dosage (four pills of indinavir taken three times daily without food and three pills of efavirenz taken once . . .</description><subject>AIDS/HIV</subject><subject>Benzoxazines</subject><subject>Drug Therapy, Combination</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Protease Inhibitors - therapeutic use</subject><subject>Humans</subject><subject>Indinavir - therapeutic use</subject><subject>Lamivudine - therapeutic use</subject><subject>Oxazines - therapeutic use</subject><subject>Research Design</subject><subject>Reverse Transcriptase Inhibitors - therapeutic use</subject><subject>RNA, Viral - blood</subject><subject>Viral Load</subject><subject>Zidovudine - therapeutic use</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp90MFKw0AQBuBFFFurL6AgxYMXie7MbLLNUUq1laoX9bpsNhtIaZK6mwj69G5JDyLiXObyzc_wM3YG_Bp4nNw8zR4ekYcRKEkgSKA9NoSYKBKCJ_tsyDlOIiFTGrAj71dbCyI9ZAPgciKJcMhOZ4X-KJ2tv8ZlPZ4v3saLurCmLZv6mB0Ueu3tyW6P2Ovd7GU6j5bP94vp7TIyFFMbaSNBcgDU3II2BSKXgEmKlEFikhjIEOaZyDOpUQDxrBDGYGGSPAEpUhqxyz5345r3zvpWVaU3dr3WtW06r2T4llKCAC9-wVXTuTr8phCDmKRSBkQ9Mq7x3tlCbVxZafepgKttb-qP3sLV-S66yyqb_7jpiwrgqgdV5VVtV9W_cd-bUnAk</recordid><startdate>20000427</startdate><enddate>20000427</enddate><creator>Casado, J L</creator><creator>Moreno, S</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20000427</creationdate><title>Efavirenz in HIV Infection</title><author>Casado, J L ; 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Staszewski et al. (Dec. 16 issue)
1
report that “the combination of efavirenz, zidovudine, and lamivudine has greater antiviral activity . . . than the combination of indinavir, zidovudine, and lamivudine.” However, their conclusions may have been overstated. Open-label studies such as theirs are less expensive, are easier to perform, and require fewer pills than randomized studies, but the design may not be adequate to compare two very different treatments, in terms of both the number of pills and the dosage (four pills of indinavir taken three times daily without food and three pills of efavirenz taken once . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>10787332</pmid><doi>10.1056/NEJM200004273421713</doi><tpages>2</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 2000-04, Vol.342 (17), p.1290-1291 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | AIDS/HIV Benzoxazines Drug Therapy, Combination HIV Infections - drug therapy HIV Protease Inhibitors - therapeutic use Humans Indinavir - therapeutic use Lamivudine - therapeutic use Oxazines - therapeutic use Research Design Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Viral Load Zidovudine - therapeutic use |
| title | Efavirenz in HIV Infection |
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