Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

Defects in PTEN, a tumor suppressor, have been found in cancers arising in a variety of human tissues. To elucidate the tumor-suppressive function of this gene, we have been analysing expression profiles of cancer cells after introduction of exogenous PTEN. Those experiments identified 99 candidate...

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Veröffentlicht in:	Oncogene 2001-07, Vol.20 (33), p.4457-4465
Hauptverfasser:	UNOKI, Motoko, NAKAMURA, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport Adult Amino Acid Sequence Ankyrin Repeat Antisense oligonucleotides Basic-Leucine Zipper Transcription Factors Biological and medical sciences Blood Proteins - genetics Blood Proteins - physiology BPOZ gene Cancer Cell cycle Cell Cycle - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cell Division - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Dual Specificity Phosphatase 1 Early Growth Response Protein 2 Egr-2 protein EGR2 gene Expressed Sequence Tags Female Flow cytometry Fundamental and applied biological sciences. Psychology G-Box Binding Factors Gene Expression Profiling Genes Genes, Tumor Suppressor Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - physiology Intracellular Signaling Peptides and Proteins Kinases Krox-20 protein Male MAP kinase phosphatase Molecular and cellular biology Molecular Sequence Data Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - pharmacology Neoplasm Proteins - physiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Oligodeoxyribonucleotides, Antisense - pharmacology Oligonucleotides Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Overexpression Phosphoprotein Phosphatases Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - physiology Protein Kinases - genetics Protein Kinases - physiology Protein Phosphatase 1 Protein Structure, Tertiary Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - physiology Proteins - genetics Proteins - physiology PTEN gene PTEN Phosphohydrolase PTEN protein PTEN-induced putative kinase Recombinant Fusion Proteins - physiology Repressor Proteins RNA Splicing Sequence Alignment Signal transduction Signal Transduction - genetics Subcellular Fractions - metabolism Transcription Transcription Factors - genetics Transcription Factors - physiology Transcriptional Activation Transfection Tumor cell lines Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology Tumor Stem Cell Assay Tumor suppressor genes Tumor Suppressor Proteins Tumors
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