Reproducible Biphasic Cutaneous Edema Induced by Topical and Repeated Application of Antigen in Sensitized Mice

An allergic dermatitis model was developed by repeated sensitization and challenge with antigen (ovalbumin, OA) over 7 months in mice. ddY mice were sensitized by i.p. injection of OA adsorbed in Al(OH)3 (1 μg OA/2 mg Al(OH)3/animal one every 3 weeks. Antigen challenge was conducted by injection of...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2000/04/01, Vol.23(4), pp.432-437
Hauptverfasser:	MIYAKE, Isao, NABE, Takeshi, YAMAMURA, Hideki, KOHNO, Shigekatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	allergic dermatitis Allergic diseases Animals Antigens - administration & dosage Benzoquinones - therapeutic use Biological and medical sciences Cyclooxygenase Inhibitors - therapeutic use Dermatitis, Allergic Contact - drug therapy Dermatitis, Allergic Contact - etiology histamine Histamine and antagonists. Allergy Histamine H1 Antagonists - therapeutic use IgE Immunopathology Indomethacin - therapeutic use Lipoxygenase Inhibitors - therapeutic use Male Medical sciences Mice Ovalbumin - administration & dosage paw edema Pharmacology. Drug treatments Pyrilamine - therapeutic use Reproducibility of Results Skin allergic diseases. Stinging insect allergies
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