AMP Deaminase Inhibitors. 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5‘-Monophosphate Mimetics

AMP deaminase (AMPDA) inhibitors increase the levels of extracellular adenosine and preserve intracellular adenylate pools in cellular models of ATP depletion and therefore represent a potential new class of antiischemic drugs. Recently we reported that replacement of the ribose 5‘-monophosphate com...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-04, Vol.43 (8), p.1519-1524
Hauptverfasser:	Bookser, Brett C, Kasibhatla, Srinivas Rao, Erion, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP Deaminase - antagonists & inhibitors AMP Deaminase - chemistry Binding Sites Biological and medical sciences Cardiovascular system Coformycin - analogs & derivatives Coformycin - chemical synthesis Coformycin - chemistry Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Malonates - chemical synthesis Malonates - chemistry Medical sciences Miscellaneous Molecular Mimicry Organophosphates - chemistry Pharmacology. Drug treatments Ribose - chemistry Structure-Activity Relationship
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