Trypsin inhibition, calcium and zinc ion binding of starch– g-poly(acrylic acid) copolymers and starch/poly(acrylic acid) mixtures for peroral peptide drug delivery

Newly synthesised starch– g-poly(acrylic acid) copolymers and starch/poly(acrylic acid) mixtures were evaluated for their in vitro inhibition potency towards the proteolytic enzyme trypsin. Their Ca 2+ and Zn 2+ binding capacity was measured. Carbopol ® 934P was used as reference polymer. Starch– g-...

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Veröffentlicht in:	Journal of controlled release 2001-08, Vol.75 (3), p.357-364
Hauptverfasser:	Ameye, D, Voorspoels, J, Foreman, P, Tsai, J, Richardson, P, Geresh, S, Remon, J.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - administration & dosage Administration, Oral Biological and medical sciences calcium Calcium - metabolism Calcium and zinc ion binding Drug Delivery Systems General pharmacology Medical sciences Oral peptide delivery Peptides - administration & dosage Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments poly(acrylic acid) starch Starch - administration & dosage Starch/poly(acrylic acid) mixtures Starch– g-poly(acrylic acid) copolymers Trypsin inhibition Trypsin Inhibitors - administration & dosage zinc Zinc - metabolism
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