hMSH6 alterations in patients with microsatellite instability-low colorectal cancer

Two microsatellite instability (MSI) phenotypes have been described in colorectal cancer (CRC): MSI-H (instability at >30% of the loci examined) and MSI-L (MSI at 1-30% of the loci examined). The MSI-H phenotype, observed in both hereditary nonpolyposis colon cancer-associated CRC and approximate...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-04, Vol.60 (8), p.2225-2231
Hauptverfasser:	PARC, Y. R, HAILING, K. C, LIANG WANG, CHRISTENSEN, E. R, CUNNINGHAM, J. M, FRENCH, A. J, BURGART, L. J, PRICE-TROSKA, T. L, ROCHE, P. C, THIBODEAU, S. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Cell Nucleus - metabolism Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA Mutational Analysis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Exons - genetics Family Health Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Testing Germ-Line Mutation - genetics hMLH1 gene hMSH2 gene hMSH6 gene Humans Immunohistochemistry Introns - genetics Male Medical sciences Middle Aged Mutation - genetics Phenotype Polymorphism, Genetic - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trinucleotide Repeat Expansion - genetics Tumors
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