Failure of Treatment for Chronic Mycobacterium abscessus Meningitis Despite Adequate Clarithromycin Levels in Cerebrospinal Fluid

We report a case of posttraumatic meningitis due to Mycobacterium abscessus, treated initially with oral clarithromycin and intravenous amikacin plus intrathecal amikacin. Despite cerebrospinal fluid (CSF) levels of clarithromycin and amikacin in excess of their in vitro minimum inhibitory concentra...

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Veröffentlicht in:	Clinical infectious diseases 2001-09, Vol.33 (5), p.745-748
Hauptverfasser:	Maniu, Calin V., Hellinger, Walter C., Chu, Sou-Yie, Palmer, Robert, Elcoro, Salvador Alvarez
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscesses Amikacin - cerebrospinal fluid Amikacin - therapeutic use Anti-Bacterial Agents - cerebrospinal fluid Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial meningitis Biological and medical sciences Brief Reports Cerebrospinal fluid Clarithromycin - cerebrospinal fluid Clarithromycin - therapeutic use Female Humans Infections Infectious diseases Lung diseases Medical sciences Medical treatment Meningitis, Bacterial - blood Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - drug therapy Microbial Sensitivity Tests Middle Aged Mycobacterium Mycobacterium - isolation & purification Mycobacterium Infections - blood Mycobacterium Infections - cerebrospinal fluid Mycobacterium Infections - drug therapy Nervous system diseases Pharmacology. Drug treatments Spinal Puncture Treatment Failure
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