Flavonol−Cinnamate Cycloadducts and Diamide Derivatives from Aglaia laxiflora

Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol−cinnamaminopyrrolidine adducts (3−6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-04, Vol.63 (4), p.473-476
Hauptverfasser:	Xu, Yuan-Jian, Wu, Xiao-Hua, Tan, B. K. H, Lai, Yee-Hing, Vittal, J. J, Imiyabir, Z, Madani, L, Khozirah, K. S, Goh, S. H
Format:	Artikel
Sprache:	eng
Schlagworte:	(+)-odorinol Aglaia amides Animals Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences chemical constituents of plants chemical structure Crystallography, X-Ray cyclopentatetrahydrobenzofuranrhamnoside cytotoxic compounds diterpenoids Drug Screening Assays, Antitumor General pharmacology Heterocyclic Compounds, 3-Ring - isolation & purification Heterocyclic Compounds, 3-Ring - pharmacology Humans leaves Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Malaysia Mass Spectrometry Medical sciences medicinal plants Mice Molecular Conformation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry precursors Rats rocaglaol spectral analysis Spectrometry, Mass, Fast Atom Bombardment trimethoxylflavonol Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol−cinnamaminopyrrolidine adducts (3−6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np990454d