Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome : Correlation with clinical and immunological features
To analyse the circulating levels of Th1 and Th2 cytokines in patients with primary Sjögren's syndrome (SS), as well as to investigate their association with clinical and immunological manifestations. We included 62 consecutive patients (58 women and 4 men) seen in our Unit. All patients fulfil...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2001-07, Vol.19 (4), p.411-415 |
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| creator | GARCIA-CARRASCO, M FONT, J FILELLA, X CERVERA, R RAMOS-CASALS, M SISO, A AYMAMI, A BALLESTA, A. M INGELMO, M |
| description | To analyse the circulating levels of Th1 and Th2 cytokines in patients with primary Sjögren's syndrome (SS), as well as to investigate their association with clinical and immunological manifestations.
We included 62 consecutive patients (58 women and 4 men) seen in our Unit. All patients fulfilled 4 or more of the European diagnostic criteria for SS. Serum levels of IL-6 (pg/mL), IL-2 (pg/mL), srIL-2 (pM), TNFalpha (pg/mL) and IL-10 (pg/mL) were determined using a solid phase enzyme immunoassav performed on microtiter plate.
When compared with the control group, high levels of Th1 (11-2, srIL-2) and Th2 (IL-6, IL-10) cytokines were detected in SS patients, although only IL-6 levels reached statistical significance. On the other hand, analysis of the mean serum concentrations of cytokines showed distinct patterns of elevated cytokines according to the organ involved, and elevated levels of IL-6 (126.5 v 20.6 pg/mL, p < 0.05) and IL-10 (10.6 v 2.2 pg/mL, p < 0.005) were observed in those patients with liver involvement. Analysis of the cytokine levels according to the presence of immunological features showed: higher levels of srIL-2 (95.6 v 54.0 pM, p < 0.05) in patients with anti-Ro/SS-A antibodies; increased levels of srIL-2 (111.4 v 59.4 pM, p < 0.05) in patients with antiLa/SS-B antibodies; higher levels of srIL-2 (90.4 vs 50.8 pM, p < 0.05) and TNFalpha (37.9 v 22.6 pg/mL, p = 0.001) in patients with RF and higher levels of IL-6 (88.0 v 23.1 pg/mL, p < 0.05) in patients with cryoglobulins and in those with hypocomplementemia (130.3 vs 21.0 pg/mL, p < 0.05).
We found a significant elevation of several circulating cytokines in some clinical and immunological subsets of patients with primary SS. These cytokine patterns may be markers for specific extraglandular involvement in SS and could be of interest in assessing the response to treatment protocols or in monitoring the disease evolution. |
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We included 62 consecutive patients (58 women and 4 men) seen in our Unit. All patients fulfilled 4 or more of the European diagnostic criteria for SS. Serum levels of IL-6 (pg/mL), IL-2 (pg/mL), srIL-2 (pM), TNFalpha (pg/mL) and IL-10 (pg/mL) were determined using a solid phase enzyme immunoassav performed on microtiter plate.
When compared with the control group, high levels of Th1 (11-2, srIL-2) and Th2 (IL-6, IL-10) cytokines were detected in SS patients, although only IL-6 levels reached statistical significance. On the other hand, analysis of the mean serum concentrations of cytokines showed distinct patterns of elevated cytokines according to the organ involved, and elevated levels of IL-6 (126.5 v 20.6 pg/mL, p < 0.05) and IL-10 (10.6 v 2.2 pg/mL, p < 0.005) were observed in those patients with liver involvement. Analysis of the cytokine levels according to the presence of immunological features showed: higher levels of srIL-2 (95.6 v 54.0 pM, p < 0.05) in patients with anti-Ro/SS-A antibodies; increased levels of srIL-2 (111.4 v 59.4 pM, p < 0.05) in patients with antiLa/SS-B antibodies; higher levels of srIL-2 (90.4 vs 50.8 pM, p < 0.05) and TNFalpha (37.9 v 22.6 pg/mL, p = 0.001) in patients with RF and higher levels of IL-6 (88.0 v 23.1 pg/mL, p < 0.05) in patients with cryoglobulins and in those with hypocomplementemia (130.3 vs 21.0 pg/mL, p < 0.05).
We found a significant elevation of several circulating cytokines in some clinical and immunological subsets of patients with primary SS. These cytokine patterns may be markers for specific extraglandular involvement in SS and could be of interest in assessing the response to treatment protocols or in monitoring the disease evolution.]]></description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 11491496</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cytokines - blood ; Female ; Humans ; Interleukin-10 - blood ; Interleukin-2 - blood ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; Receptors, Interleukin-2 - blood ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - immunology ; Sjogren's Syndrome - physiopathology ; Th1 Cells - immunology ; Th2 Cells - immunology ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Clinical and experimental rheumatology, 2001-07, Vol.19 (4), p.411-415</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14085912$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11491496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GARCIA-CARRASCO, M</creatorcontrib><creatorcontrib>FONT, J</creatorcontrib><creatorcontrib>FILELLA, X</creatorcontrib><creatorcontrib>CERVERA, R</creatorcontrib><creatorcontrib>RAMOS-CASALS, M</creatorcontrib><creatorcontrib>SISO, A</creatorcontrib><creatorcontrib>AYMAMI, A</creatorcontrib><creatorcontrib>BALLESTA, A. M</creatorcontrib><creatorcontrib>INGELMO, M</creatorcontrib><title>Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome : Correlation with clinical and immunological features</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description><![CDATA[To analyse the circulating levels of Th1 and Th2 cytokines in patients with primary Sjögren's syndrome (SS), as well as to investigate their association with clinical and immunological manifestations.
We included 62 consecutive patients (58 women and 4 men) seen in our Unit. All patients fulfilled 4 or more of the European diagnostic criteria for SS. Serum levels of IL-6 (pg/mL), IL-2 (pg/mL), srIL-2 (pM), TNFalpha (pg/mL) and IL-10 (pg/mL) were determined using a solid phase enzyme immunoassav performed on microtiter plate.
When compared with the control group, high levels of Th1 (11-2, srIL-2) and Th2 (IL-6, IL-10) cytokines were detected in SS patients, although only IL-6 levels reached statistical significance. On the other hand, analysis of the mean serum concentrations of cytokines showed distinct patterns of elevated cytokines according to the organ involved, and elevated levels of IL-6 (126.5 v 20.6 pg/mL, p < 0.05) and IL-10 (10.6 v 2.2 pg/mL, p < 0.005) were observed in those patients with liver involvement. Analysis of the cytokine levels according to the presence of immunological features showed: higher levels of srIL-2 (95.6 v 54.0 pM, p < 0.05) in patients with anti-Ro/SS-A antibodies; increased levels of srIL-2 (111.4 v 59.4 pM, p < 0.05) in patients with antiLa/SS-B antibodies; higher levels of srIL-2 (90.4 vs 50.8 pM, p < 0.05) and TNFalpha (37.9 v 22.6 pg/mL, p = 0.001) in patients with RF and higher levels of IL-6 (88.0 v 23.1 pg/mL, p < 0.05) in patients with cryoglobulins and in those with hypocomplementemia (130.3 vs 21.0 pg/mL, p < 0.05).
We found a significant elevation of several circulating cytokines in some clinical and immunological subsets of patients with primary SS. These cytokine patterns may be markers for specific extraglandular involvement in SS and could be of interest in assessing the response to treatment protocols or in monitoring the disease evolution.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-2 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Interleukin-2 - blood</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - immunology</subject><subject>Sjogren's Syndrome - physiopathology</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0N9KwzAUBvAiipvTV5DcqFfFpGnaxjsp_oOBF07YXUnT0y0zTWrSKnsG38cX8MWsriIcOHD48cF39oIpYZyGmGfL_WCKKY_CjCXLSXDk_QbjKGFJehhMCIn5MMk0-MiVk70WnTIrpOENtEe2Ros1uVysIyS3nX1RBjxSBrWDAtN59K66NWqdaoTboqfN1-fKgbnwyG9N5WwD6Arl1jn4ibVmx6VWRkmhkTAVUk3TG6vt6vdSg-h6B_44OKiF9nAy7lnwfHuzyO_D-ePdQ349D9uIpl0IsRBpmUkuOIvKrCKyympGeCyrmqeYlyXO0hJKSaq4zmKBOWUJZ7ymMsFAUzoLzne5rbOvPfiuaJSXoLUwYHtfpAQnPKJ8gKcj7MsGqmKsXPy9bwBnIxB-aFI7YaTy_y7GGeMkot_TQn2s</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>GARCIA-CARRASCO, M</creator><creator>FONT, J</creator><creator>FILELLA, X</creator><creator>CERVERA, R</creator><creator>RAMOS-CASALS, M</creator><creator>SISO, A</creator><creator>AYMAMI, A</creator><creator>BALLESTA, A. M</creator><creator>INGELMO, M</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome : Correlation with clinical and immunological features</title><author>GARCIA-CARRASCO, M ; FONT, J ; FILELLA, X ; CERVERA, R ; RAMOS-CASALS, M ; SISO, A ; AYMAMI, A ; BALLESTA, A. M ; INGELMO, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-e4aa7b8c9a952b8d1cd8f5194cdf9709bb087bebc1d4f84a09356959f3c60e373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-2 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Interleukin-2 - blood</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - immunology</topic><topic>Sjogren's Syndrome - physiopathology</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GARCIA-CARRASCO, M</creatorcontrib><creatorcontrib>FONT, J</creatorcontrib><creatorcontrib>FILELLA, X</creatorcontrib><creatorcontrib>CERVERA, R</creatorcontrib><creatorcontrib>RAMOS-CASALS, M</creatorcontrib><creatorcontrib>SISO, A</creatorcontrib><creatorcontrib>AYMAMI, A</creatorcontrib><creatorcontrib>BALLESTA, A. M</creatorcontrib><creatorcontrib>INGELMO, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GARCIA-CARRASCO, M</au><au>FONT, J</au><au>FILELLA, X</au><au>CERVERA, R</au><au>RAMOS-CASALS, M</au><au>SISO, A</au><au>AYMAMI, A</au><au>BALLESTA, A. M</au><au>INGELMO, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome : Correlation with clinical and immunological features</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>19</volume><issue>4</issue><spage>411</spage><epage>415</epage><pages>411-415</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract><![CDATA[To analyse the circulating levels of Th1 and Th2 cytokines in patients with primary Sjögren's syndrome (SS), as well as to investigate their association with clinical and immunological manifestations.
We included 62 consecutive patients (58 women and 4 men) seen in our Unit. All patients fulfilled 4 or more of the European diagnostic criteria for SS. Serum levels of IL-6 (pg/mL), IL-2 (pg/mL), srIL-2 (pM), TNFalpha (pg/mL) and IL-10 (pg/mL) were determined using a solid phase enzyme immunoassav performed on microtiter plate.
When compared with the control group, high levels of Th1 (11-2, srIL-2) and Th2 (IL-6, IL-10) cytokines were detected in SS patients, although only IL-6 levels reached statistical significance. On the other hand, analysis of the mean serum concentrations of cytokines showed distinct patterns of elevated cytokines according to the organ involved, and elevated levels of IL-6 (126.5 v 20.6 pg/mL, p < 0.05) and IL-10 (10.6 v 2.2 pg/mL, p < 0.005) were observed in those patients with liver involvement. Analysis of the cytokine levels according to the presence of immunological features showed: higher levels of srIL-2 (95.6 v 54.0 pM, p < 0.05) in patients with anti-Ro/SS-A antibodies; increased levels of srIL-2 (111.4 v 59.4 pM, p < 0.05) in patients with antiLa/SS-B antibodies; higher levels of srIL-2 (90.4 vs 50.8 pM, p < 0.05) and TNFalpha (37.9 v 22.6 pg/mL, p = 0.001) in patients with RF and higher levels of IL-6 (88.0 v 23.1 pg/mL, p < 0.05) in patients with cryoglobulins and in those with hypocomplementemia (130.3 vs 21.0 pg/mL, p < 0.05).
We found a significant elevation of several circulating cytokines in some clinical and immunological subsets of patients with primary SS. These cytokine patterns may be markers for specific extraglandular involvement in SS and could be of interest in assessing the response to treatment protocols or in monitoring the disease evolution.]]></abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>11491496</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Clinical and experimental rheumatology, 2001-07, Vol.19 (4), p.411-415 |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Cytokines - blood Female Humans Interleukin-10 - blood Interleukin-2 - blood Interleukin-6 - blood Male Medical sciences Middle Aged Receptors, Interleukin-2 - blood Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sjogren's Syndrome - complications Sjogren's Syndrome - immunology Sjogren's Syndrome - physiopathology Th1 Cells - immunology Th2 Cells - immunology Tumor Necrosis Factor-alpha - analysis |
| title | Circulating levels of Th1/Th2 cytokines in patients with primary Sjögren's syndrome : Correlation with clinical and immunological features |
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