Potent antiretroviral therapy initiates normalization of hypergammaglobulinemia and a decline in HIV type 1-specific antibody responses

Next to a profound T cell immunodeficiency, HIV-1 infection induces activation and dysfunction of B cells, resulting in hypergammaglobulinemia. Whereas T cell immune reconstitution with potent antiretroviral therapy has been extensively documented, limited data are available on B cell immune reconst...

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Veröffentlicht in:	AIDS research and human retroviruses 2001-07, Vol.17 (11), p.1003-1008
Hauptverfasser:	NOTERMANS, Daan W, DE JONG, J. Jacques, GOUDSMIT, Jaap, BAKKER, Margreet, ROOS, Marijke T. L, NIJHOLT, Liekle, CREMERS, Jeanne, HELLINGS, Jan-Albert, DANNER, Sven A, DE RONDE, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents antiretroviral therapy Antiviral agents Biological and medical sciences CD4-Positive T-Lymphocytes - immunology Drug Therapy, Combination Female Fundamental and applied biological sciences. Psychology glycoprotein gp120 glycoprotein gp24 HIV Antibodies - drug effects HIV Core Protein p24 - drug effects HIV Core Protein p24 - immunology HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - immunology HIV Infections - drug therapy HIV Infections - immunology HIV-1 Human immunodeficiency virus 1 Humans Hypergammaglobulinemia Hypergammaglobulinemia - drug therapy Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin G - immunology Immunopathology Lamivudine - therapeutic use Male Medical sciences Microbiology Middle Aged Pharmacology. Drug treatments Retrospective Studies Ritonavir - therapeutic use RNA, Viral - blood Treatment Failure Viral Load Zidovudine - therapeutic use
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