Ras and Rho regulation of the cell cycle and oncogenesis

The important contribution of aberrant Ras activation in oncogenesis is well established. Our knowledge of the signaling pathways that are regulated by Ras is considerable. However, the number of downstream effectors of Ras continues to increase and our understanding of the role of these effector si...

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Veröffentlicht in:	Cancer Letters 2001-09, Vol.171 (1), p.1-10
Hauptverfasser:	Pruitt, Kevin, Der, Channing J.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells - cytology 3T3 Cells - metabolism Animals Biological and medical sciences Cell Cycle - genetics Cell Cycle - physiology Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Cell Division - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cip1 gene cycli D1 cyclin D1 Cyclin D1 - genetics Cyclin D1 - physiology Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - physiology Cyclins - physiology Epithelial Cells - cytology Epithelial Cells - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Humans MAP Kinase Signaling System - physiology Mice Models, Biological Molecular and cellular biology p21 protein p21CIP1 p27KIP1 Rac Raf ras Proteins - physiology Retinoblastoma Protein - physiology Rho rho GTP-Binding Proteins - physiology Rho protin Signal Transduction - physiology Tumor Suppressor Proteins
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