Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3

The purpose of this study was to investigate the anti-proliferative and pro-apoptotic effects of the butyrate analogues, tributyrin (TB) and phenylbutyrate (PB), in a colon cancer model. We demonstrate that HT-29 colon cancer cells exposed to PB and TB result in growth inhibition associated with an...

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Veröffentlicht in:	Cancer letters 2001-09, Vol.171 (1), p.57-65
Hauptverfasser:	Clarke, Kevin O, Feinman, Rena, Harrison, Lawrence E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - pathology Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Butyrates - pharmacology Caspase 3 Caspases - metabolism CDC2-CDC28 Kinases Cell cycle control Cell Cycle Proteins Chemotherapy Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinases - metabolism Differentiation DNA-Binding Proteins - metabolism E2F Transcription Factors E2F4 Transcription Factor Enzyme Activation - drug effects Fatty acid G1 Phase - drug effects Medical sciences Neoplasm Proteins - metabolism Nuclear Proteins - metabolism Pharmacology. Drug treatments Phenotype Phenylbutyrate Phenylbutyrates - pharmacology Phosphorylation - drug effects Protein Processing, Post-Translational - drug effects Protein-Serine-Threonine Kinases - metabolism Retinoblastoma Protein - metabolism Transcription Factors - metabolism Tributyrin Triglycerides - pharmacology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology
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