Chlamydia pneumoniae and Chlamydial Heat Shock Protein 60 Stimulate Proliferation of Human Vascular Smooth Muscle Cells via Toll-Like Receptor 4 and p44/p42 Mitogen-Activated Protein Kinase Activation

ABSTRACT—An early component of atherogenesis is abnormal vascular smooth muscle cell (VSMC) proliferation. The presence of Chlamydia pneumoniae in many atherosclerotic lesions raises the possibility that this organism plays a causal role in atherogenesis. In this study, C pneumoniae elementary bodie...

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Veröffentlicht in:	Circulation research 2001-08, Vol.89 (3), p.244-250
Hauptverfasser:	Sasu, Sebastian, LaVerda, David, Qureshi, Nilofer, Golenbock, Douglas T, Beasley, Debbie
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Bacterial Proteins - pharmacology Biological and medical sciences Bromodeoxyuridine Butadienes - pharmacology Cell Division - drug effects Cells, Cultured Chaperonin 60 - antagonists & inhibitors Chaperonin 60 - metabolism Chaperonin 60 - pharmacology Chlamydophila Infections - metabolism Chlamydophila pneumoniae - metabolism Drosophila Proteins Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Experimental bacterial diseases and models Flavonoids - pharmacology Hot Temperature Humans Infectious diseases Lipid A - analogs & derivatives Lipid A - pharmacology Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - microbiology Nitriles - pharmacology Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Saphenous Vein Toll-Like Receptor 4 Toll-Like Receptors
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