Solar simulated irradiation modulates gene expression and activity of antioxidant enzymes in cultured human dermal fibroblasts

: Exposure of skin to solar irradiation generates reactive oxygen species that damage DNA, membranes, mitochondria and proteins. To protect against such damage, skin cells have evolved antioxidant enzymes including glutathione peroxidase (GSH‐Px), copper and zinc‐dependent superoxide dismutase (SOD1...

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Veröffentlicht in:	Experimental dermatology 2001-08, Vol.10 (4), p.272-279
Hauptverfasser:	Leccia, M.-T., Yaar, M., Allen, N., Gleason, M., Gilchrest, B. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant enzymes Biological and medical sciences Biological effects of radiation Catalase - metabolism Cells, Cultured Fibroblasts - enzymology Fibroblasts - radiation effects Fundamental and applied biological sciences. Psychology Gene Expression - radiation effects Glutathione Peroxidase - metabolism Humans Non ionizing radiations. Hertzian waves. Biooptics Oxidoreductases - metabolism reactive oxygen species Skin - cytology Skin - enzymology Skin - radiation effects Sunlight Superoxide Dismutase - metabolism Superoxide Dismutase-1 Tissues, organs and organisms biophysics Ultraviolet Rays
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