Polyhistidine-tagged hepatitis B core particles as carriers of HIV-1/gp120 epitopes of different HIV-1 subtypes

The hepatitis B core antigen is a widely accepted carrier particle to enhance the immunogenicity of foreign epitopes. From electron cryomicroscopy, the immunodominant region between amino acid positions 79 to 81 is known to protrude from the surface of the shells. It can be replaced by heterologous...

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Veröffentlicht in:	Biological chemistry 2000-03, Vol.381 (3), p.231-231
Hauptverfasser:	Wizemann, H, Weiland, F, Pfaff, E, von Brunn, A
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Animals Antibodies, Viral - biosynthesis Escherichia coli Gene Expression Hepatitis B Core Antigens - immunology Histidine HIV Envelope Protein gp120 - biosynthesis HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV Infections - immunology HIV-1 - classification HIV-1 - immunology Human immunodeficiency virus 1 Humans Immunodominant Epitopes - immunology Mice Mice, Inbred BALB C Microscopy, Electron Molecular Sequence Data Peptide Fragments - biosynthesis Peptide Fragments - genetics Structure-Activity Relationship
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