Transfer of methohexital across the perfused human placenta

Study Objectives: To evaluate the transfer properties of methohexital and the influence of protein binding using the in vitro human placental perfusion model. Design: Fresh term human placentae from healthy parturients were perfused bidirectionally via a cannulated fetal chorionic artery and vein an...

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Veröffentlicht in:	Journal of clinical anesthesia 2000-02, Vol.12 (1), p.25-30
Hauptverfasser:	Herman, Norman L, Li, An-Tai, Van Decar, Tama K, Johnson, Raymond F, Bjoraker, Robert W, Downing, John W, Jones, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Albumins - metabolism Anesthetic Anesthetics, Intravenous - pharmacokinetics Anesthetics. Neuromuscular blocking agents Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Antipyrine - pharmacokinetics Biological and medical sciences Chorion - blood supply Chorionic Villi Chromatography, High Pressure Liquid Female Glucose - analysis Humans intravenous Lactic Acid - analysis Maternal-Fetal Exchange Medical sciences methohexital Methohexital - pharmacokinetics Neuropharmacology Perfusion pharmacokinetics Pharmacology. Drug treatments Placenta - metabolism placental transfer Pregnancy protein binding Protein Binding - drug effects Reproducibility of Results Tissue Survival
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