Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation
The role of the neuroendocrine system in the development of cell-mediated immunity has been studied in fetal rats. The spontaneous and mitogen-induced proliferation of liver lymphocytes and thymocytes was evaluated in vitro in rats at the 22nd prenatal day following surgical ablation of the forebrai...
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| Veröffentlicht in: | Journal of reproductive immunology 2000-05, Vol.47 (1), p.17-32 |
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| container_title | Journal of reproductive immunology |
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| creator | Zakharova, L.A Malyukova, I.V Proshlyakova, E.V Potapova, A.A Sapronova, A.Y Ershov, P.V Ugrumov, M.V |
| description | The role of the neuroendocrine system in the development of cell-mediated immunity has been studied in fetal rats. The spontaneous and mitogen-induced proliferation of liver lymphocytes and thymocytes was evaluated in vitro in rats at the 22nd prenatal day following surgical ablation of the forebrain (encephalectomy) or of the entire brain and pituitary (decapitation) in rat fetuses in utero at the 18th day. Non-operated and sham-operated fetuses served as controls. The ablation of the entire brain and pituitary in rat fetuses resulted in an increase (40–60%) of spontaneous proliferation of liver and thymic cells in comparison with sham-operated fetuses. The ablation of the forebrain including the hypothalamus caused a decrease in the mitogenic proliferative response of thymocytes and liver lymphocytes for 40 and 20%, respectively. The ablation of the entire brain including the hypothalamus and pituitary resulted in a 80% decrease of the proliferative response of thymocytes and in the full suppression of proliferation of liver lymphocytes. The immune proliferative response was restored by the LHRH administration either systemically to operated fetuses (0.2 μg/fetus) or to the cell culture (10
−9 and 10
−7 M). It was concluded that the central nervous system was important for maturation of the immune system in rats during the prenatal period. In particular, neuroendocrine system are likely to play a major role as LHRH treatment in vitro and in vivo appeared to contribute to this regulation. |
| doi_str_mv | 10.1016/S0165-0378(00)00057-7 |
| format | Article |
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−9 and 10
−7 M). It was concluded that the central nervous system was important for maturation of the immune system in rats during the prenatal period. In particular, neuroendocrine system are likely to play a major role as LHRH treatment in vitro and in vivo appeared to contribute to this regulation.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/S0165-0378(00)00057-7</identifier><identifier>PMID: 10779587</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Cell Division - immunology ; Cell-mediated immunity ; Cells, Cultured ; Development ; Embryo, Mammalian - cytology ; Embryo, Mammalian - immunology ; Female ; Gonadotropin-Releasing Hormone - pharmacology ; Gonadotropin-Releasing Hormone - physiology ; Hypothalamo-Hypophyseal System - cytology ; Hypothalamo-Hypophyseal System - immunology ; Hypothalamus ; Immunity, Cellular ; LHRH ; Liver - cytology ; Liver - embryology ; Liver - immunology ; luteinizing hormone-releasing hormone ; Lymphocyte Activation - immunology ; Lymphocytes - immunology ; Mitogens - pharmacology ; Neuroimmunomodulation ; Pregnancy ; Rats ; Rats, Wistar ; Thymus Gland - cytology ; Thymus Gland - embryology ; Thymus Gland - immunology</subject><ispartof>Journal of reproductive immunology, 2000-05, Vol.47 (1), p.17-32</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-9a75acd5040dfe54a00ff4e075f5e1347f12ceb779d983a8fd0aed89960971b43</citedby><cites>FETCH-LOGICAL-c487t-9a75acd5040dfe54a00ff4e075f5e1347f12ceb779d983a8fd0aed89960971b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-0378(00)00057-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1397251$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10779587$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zakharova, L.A</creatorcontrib><creatorcontrib>Malyukova, I.V</creatorcontrib><creatorcontrib>Proshlyakova, E.V</creatorcontrib><creatorcontrib>Potapova, A.A</creatorcontrib><creatorcontrib>Sapronova, A.Y</creatorcontrib><creatorcontrib>Ershov, P.V</creatorcontrib><creatorcontrib>Ugrumov, M.V</creatorcontrib><title>Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>The role of the neuroendocrine system in the development of cell-mediated immunity has been studied in fetal rats. The spontaneous and mitogen-induced proliferation of liver lymphocytes and thymocytes was evaluated in vitro in rats at the 22nd prenatal day following surgical ablation of the forebrain (encephalectomy) or of the entire brain and pituitary (decapitation) in rat fetuses in utero at the 18th day. Non-operated and sham-operated fetuses served as controls. The ablation of the entire brain and pituitary in rat fetuses resulted in an increase (40–60%) of spontaneous proliferation of liver and thymic cells in comparison with sham-operated fetuses. The ablation of the forebrain including the hypothalamus caused a decrease in the mitogenic proliferative response of thymocytes and liver lymphocytes for 40 and 20%, respectively. The ablation of the entire brain including the hypothalamus and pituitary resulted in a 80% decrease of the proliferative response of thymocytes and in the full suppression of proliferation of liver lymphocytes. The immune proliferative response was restored by the LHRH administration either systemically to operated fetuses (0.2 μg/fetus) or to the cell culture (10
−9 and 10
−7 M). It was concluded that the central nervous system was important for maturation of the immune system in rats during the prenatal period. In particular, neuroendocrine system are likely to play a major role as LHRH treatment in vitro and in vivo appeared to contribute to this regulation.</description><subject>Animals</subject><subject>Cell Division - immunology</subject><subject>Cell-mediated immunity</subject><subject>Cells, Cultured</subject><subject>Development</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryo, Mammalian - immunology</subject><subject>Female</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gonadotropin-Releasing Hormone - physiology</subject><subject>Hypothalamo-Hypophyseal System - cytology</subject><subject>Hypothalamo-Hypophyseal System - immunology</subject><subject>Hypothalamus</subject><subject>Immunity, Cellular</subject><subject>LHRH</subject><subject>Liver - cytology</subject><subject>Liver - embryology</subject><subject>Liver - immunology</subject><subject>luteinizing hormone-releasing hormone</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes - immunology</subject><subject>Mitogens - pharmacology</subject><subject>Neuroimmunomodulation</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thymus Gland - cytology</subject><subject>Thymus Gland - embryology</subject><subject>Thymus Gland - immunology</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-r1DAQxYMo3vXqR1DyIKIP1Unb7LS-iFzUFRYE_zyHbDpxI21Tk1Toq5_cdHdR3-5LApnfycycw9hjAS8FiO2rL_mQBVTYPAd4AQASC7zDNqLBssAtVHfZ5i9yxR7E-ANAILTiPrsSgNjKBjfs926ZfDrqXg--mFyaXdJh4caPKfiee8vTkbihvi8G6pxO1HE3DPPo0sLdyINOnIZDWHx8zbOCVsl-93l3KtL3udfJ-XF97ZdhOnqzJOJTJp2lcKo9ZPes7iM9utzX7Nv7d19vdsX-04ePN2_3hakbTEWrUWrTSaihsyRrDWBtTYDSShJVjVaUhg55sa5tKt3YDjR1TdtuoUVxqKtr9uz8b-7-c6aY1ODiupkeyc9RoYBtBbK8FRQoS5AVZFCeQRN8jIGsmoIbsn9KgFpTUqeU1BqBAlCnlBRm3ZNLg_mQXf1PdY4lA08vgI5G9zbo0bj4j6taLKXI2JszRtm2X46CisbRaHJQgUxSnXe3TPIHF-Kwkg</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Zakharova, L.A</creator><creator>Malyukova, I.V</creator><creator>Proshlyakova, E.V</creator><creator>Potapova, A.A</creator><creator>Sapronova, A.Y</creator><creator>Ershov, P.V</creator><creator>Ugrumov, M.V</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation</title><author>Zakharova, L.A ; Malyukova, I.V ; Proshlyakova, E.V ; Potapova, A.A ; Sapronova, A.Y ; Ershov, P.V ; Ugrumov, M.V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-9a75acd5040dfe54a00ff4e075f5e1347f12ceb779d983a8fd0aed89960971b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Cell Division - immunology</topic><topic>Cell-mediated immunity</topic><topic>Cells, Cultured</topic><topic>Development</topic><topic>Embryo, Mammalian - cytology</topic><topic>Embryo, Mammalian - immunology</topic><topic>Female</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gonadotropin-Releasing Hormone - physiology</topic><topic>Hypothalamo-Hypophyseal System - cytology</topic><topic>Hypothalamo-Hypophyseal System - immunology</topic><topic>Hypothalamus</topic><topic>Immunity, Cellular</topic><topic>LHRH</topic><topic>Liver - cytology</topic><topic>Liver - embryology</topic><topic>Liver - immunology</topic><topic>luteinizing hormone-releasing hormone</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes - immunology</topic><topic>Mitogens - pharmacology</topic><topic>Neuroimmunomodulation</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thymus Gland - cytology</topic><topic>Thymus Gland - embryology</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zakharova, L.A</creatorcontrib><creatorcontrib>Malyukova, I.V</creatorcontrib><creatorcontrib>Proshlyakova, E.V</creatorcontrib><creatorcontrib>Potapova, A.A</creatorcontrib><creatorcontrib>Sapronova, A.Y</creatorcontrib><creatorcontrib>Ershov, P.V</creatorcontrib><creatorcontrib>Ugrumov, M.V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zakharova, L.A</au><au>Malyukova, I.V</au><au>Proshlyakova, E.V</au><au>Potapova, A.A</au><au>Sapronova, A.Y</au><au>Ershov, P.V</au><au>Ugrumov, M.V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>47</volume><issue>1</issue><spage>17</spage><epage>32</epage><pages>17-32</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>The role of the neuroendocrine system in the development of cell-mediated immunity has been studied in fetal rats. The spontaneous and mitogen-induced proliferation of liver lymphocytes and thymocytes was evaluated in vitro in rats at the 22nd prenatal day following surgical ablation of the forebrain (encephalectomy) or of the entire brain and pituitary (decapitation) in rat fetuses in utero at the 18th day. Non-operated and sham-operated fetuses served as controls. The ablation of the entire brain and pituitary in rat fetuses resulted in an increase (40–60%) of spontaneous proliferation of liver and thymic cells in comparison with sham-operated fetuses. The ablation of the forebrain including the hypothalamus caused a decrease in the mitogenic proliferative response of thymocytes and liver lymphocytes for 40 and 20%, respectively. The ablation of the entire brain including the hypothalamus and pituitary resulted in a 80% decrease of the proliferative response of thymocytes and in the full suppression of proliferation of liver lymphocytes. The immune proliferative response was restored by the LHRH administration either systemically to operated fetuses (0.2 μg/fetus) or to the cell culture (10
−9 and 10
−7 M). It was concluded that the central nervous system was important for maturation of the immune system in rats during the prenatal period. In particular, neuroendocrine system are likely to play a major role as LHRH treatment in vitro and in vivo appeared to contribute to this regulation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10779587</pmid><doi>10.1016/S0165-0378(00)00057-7</doi><tpages>16</tpages></addata></record> |
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| ispartof | Journal of reproductive immunology, 2000-05, Vol.47 (1), p.17-32 |
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| subjects | Animals Cell Division - immunology Cell-mediated immunity Cells, Cultured Development Embryo, Mammalian - cytology Embryo, Mammalian - immunology Female Gonadotropin-Releasing Hormone - pharmacology Gonadotropin-Releasing Hormone - physiology Hypothalamo-Hypophyseal System - cytology Hypothalamo-Hypophyseal System - immunology Hypothalamus Immunity, Cellular LHRH Liver - cytology Liver - embryology Liver - immunology luteinizing hormone-releasing hormone Lymphocyte Activation - immunology Lymphocytes - immunology Mitogens - pharmacology Neuroimmunomodulation Pregnancy Rats Rats, Wistar Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - immunology |
| title | Hypothalamo-pituitary control of the cell-mediated immunity in rat embryos: role of LHRH in regulation of lymphocyte proliferation |
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