Matrix Metalloproteinase Inhibition After Myocardial Infarction: A New Approach to Prevent Heart Failure?

ABSTRACT—Increased activity of matrix metalloproteinases (MMPs) has been implicated in numerous disease processes, including tumor growth and metastasis, arthritis, and periodontal disease. It is now becoming increasingly clear that extracellular matrix degradation by MMPs is also involved in the pa...

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Veröffentlicht in:	Circulation research 2001-08, Vol.89 (3), p.201-210
Hauptverfasser:	Creemers, Esther E.J.M, Cleutjens, Jack P.M, Smits, Jos F.M, Daemen, Mat J.A.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Disease Models, Animal Disease Progression Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Extracellular Matrix - metabolism Gene Expression Regulation - physiology Heart Failure - etiology Heart Failure - prevention & control Humans Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - metabolism Medical sciences Miscellaneous Myocardial Infarction - complications Myocardial Infarction - drug therapy Myocardial Infarction - enzymology Myocardium - enzymology Pharmacology. Drug treatments Plasminogen - metabolism Tissue Inhibitor of Metalloproteinases - metabolism Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control
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