$Mechanoelectrical feedback : Role of β-adrenergic receptor activation in mediating load-dependent shortening of ventricular action potential and refractoriness$

Mechanoelectrical feedback : Role of β-adrenergic receptor activation in mediating load-dependent shortening of ventricular action potential and refractoriness

Augmented preload increases myocardial excitability by shortening action potential duration (APD). The mechanism governing this phenomenon is unknown. Because myocardial stretch increases intracellular cAMP, we hypothesized that load-dependent changes in myocardial excitability are mediated by beta-...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2001-07, Vol.104 (4), p.486-490
Hauptverfasser:	LERMAN, Bruce B, ENGELSTEIN, Erica D, BURKHOFF, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adrenergic beta-Antagonists - pharmacology Adrenergic Uptake Inhibitors - pharmacology Animals Biological and medical sciences Biomechanical Phenomena Cardiac dysrhythmias Cardiology. Vascular system Dogs Electrophysiology Feedback - physiology Heart Heart Ventricles - drug effects Heart Ventricles - physiopathology Medical sciences Propranolol - pharmacology Receptors, Adrenergic, beta - metabolism Receptors, Adrenergic, beta - physiology Reserpine - pharmacology Ventricular Function Ventricular Pressure - drug effects
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