An in vitro study of the effects of isoflurane on oxygen transfer
A common anesthetic technique utilized during cardiopulmonary bypass (CPB) includes the use of various inhalation agents, such as isoflurane. The purpose of this study was to evaluate the effects of this agent on oxygen transfer during CPB. An in vitro model was designed using bovine blood. Blood fl...
Gespeichert in:
| Veröffentlicht in: | Perfusion 2001-07, Vol.16 (4), p.293-299 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 299 |
|---|---|
| container_issue | 4 |
| container_start_page | 293 |
| container_title | Perfusion |
| container_volume | 16 |
| creator | Muhle, Michelle L Stammers, Alfred H Tremain, Kimberly D Niimi, Kevin S Glogowski, Kimberly R Trowbridge, Cody C Yang, Tianyu |
| description | A common anesthetic technique utilized during cardiopulmonary bypass (CPB) includes the use of various inhalation agents, such as isoflurane. The purpose of this study was to evaluate the effects of this agent on oxygen transfer during CPB.
An in vitro model was designed using bovine blood. Blood flow was held constant at 2 l/min, while gas flow was manipulated at 1 and 3 l/min. The percentage of inspired oxygen (FiO2) was set at 50 and 100%, and isoflurane was manipulated to 1.0, 3.0 and 5.0%. Blood gas analysis, oxygen transfer, and inlet and outlet isoflurane concentrations were measured at each of the given conditions. A total of 12 trials with four oxygenators were conducted.
In the four oxygenators used in our study, no significant differences in oxygenator performance were found. At conditions of 1 l/min gas flow, 50% FiO2 and 1% isoflurane, there were no significant changes in O2 transfer between baseline and measurements taken during isoflurane administration (100.18 ± 12.49 vs 102.35 ± 10.99 ml O2/min, p=0.8031). At 3 l/min gas flow, 100% FiO2 and 5% isoflurane, no significant differences were found (142.35 ± 10.76 vs 154.04 ± 8.95 ml O2/min, p=0.1459). The only significant differences found for oxygen transfer were between 50 and 100% FiO2, all other conditions being set equal (102.35 ± 10.99 vs 137.68 ± 8.62 ml O2/min, p=0.0023).
In conclusion, increasing concentrations of isoflurane up to 5% does not affect the efficiency of oxygen transfer in an in vitro circuit. Further studies are necessary to evaluate the effects in an in vivo setting. |
| doi_str_mv | 10.1177/026765910101600405 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71062166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_026765910101600405</sage_id><sourcerecordid>1082162221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-9eb53e365d5c0101e9f4635602dba6352cc74857b34376e2ccf74218d20687ac3</originalsourceid><addsrcrecordid>eNp1kEtLw0AUhQdRbK3-ARcyuHAXOzfzSpZFfEHBjYK7kEzu1JQ2U2cSsf_eCS0oitzF3APfPXM4hJwDuwbQespSpZXMgcVRjAkmD8gYhNYJALwekvEAJAMxIichLFlkhODHZAQgMpWJbExms5Y2Lf1oOu9o6Pp6S52l3RtStBZNFwbZBGdXvS9bpK6l7nO7wJZ2UQeL_pQc2XIV8Gz_TsjL3e3zzUMyf7p_vJnNE8OV6pIcK8mRK1lLMwTG3ArFpWJpXZVxSY3RIpO64oJrhVFaLVLI6pSpTJeGT8jVznfj3XuPoSvWTTC4WsVYrg-FBqZSUCqCl7_Apet9G7MVkOdSZnnOIpTuIONdCB5tsfHNuvTbAlgxtFv8bTceXeyd-2qN9ffJvs4ITHdAKBf449v_Lb8AfVp_tA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199558990</pqid></control><display><type>article</type><title>An in vitro study of the effects of isoflurane on oxygen transfer</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Muhle, Michelle L ; Stammers, Alfred H ; Tremain, Kimberly D ; Niimi, Kevin S ; Glogowski, Kimberly R ; Trowbridge, Cody C ; Yang, Tianyu</creator><creatorcontrib>Muhle, Michelle L ; Stammers, Alfred H ; Tremain, Kimberly D ; Niimi, Kevin S ; Glogowski, Kimberly R ; Trowbridge, Cody C ; Yang, Tianyu</creatorcontrib><description>A common anesthetic technique utilized during cardiopulmonary bypass (CPB) includes the use of various inhalation agents, such as isoflurane. The purpose of this study was to evaluate the effects of this agent on oxygen transfer during CPB.
An in vitro model was designed using bovine blood. Blood flow was held constant at 2 l/min, while gas flow was manipulated at 1 and 3 l/min. The percentage of inspired oxygen (FiO2) was set at 50 and 100%, and isoflurane was manipulated to 1.0, 3.0 and 5.0%. Blood gas analysis, oxygen transfer, and inlet and outlet isoflurane concentrations were measured at each of the given conditions. A total of 12 trials with four oxygenators were conducted.
In the four oxygenators used in our study, no significant differences in oxygenator performance were found. At conditions of 1 l/min gas flow, 50% FiO2 and 1% isoflurane, there were no significant changes in O2 transfer between baseline and measurements taken during isoflurane administration (100.18 ± 12.49 vs 102.35 ± 10.99 ml O2/min, p=0.8031). At 3 l/min gas flow, 100% FiO2 and 5% isoflurane, no significant differences were found (142.35 ± 10.76 vs 154.04 ± 8.95 ml O2/min, p=0.1459). The only significant differences found for oxygen transfer were between 50 and 100% FiO2, all other conditions being set equal (102.35 ± 10.99 vs 137.68 ± 8.62 ml O2/min, p=0.0023).
In conclusion, increasing concentrations of isoflurane up to 5% does not affect the efficiency of oxygen transfer in an in vitro circuit. Further studies are necessary to evaluate the effects in an in vivo setting.</description><identifier>ISSN: 0267-6591</identifier><identifier>EISSN: 1477-111X</identifier><identifier>DOI: 10.1177/026765910101600405</identifier><identifier>PMID: 11486848</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Anesthetics, Inhalation - pharmacology ; Animals ; Blood Flow Velocity ; Blood Gas Analysis ; Cattle ; Dose-Response Relationship, Drug ; Isoflurane - analysis ; Isoflurane - pharmacology ; Oxygen - metabolism ; Oxygenators, Membrane</subject><ispartof>Perfusion, 2001-07, Vol.16 (4), p.293-299</ispartof><rights>2001 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-9eb53e365d5c0101e9f4635602dba6352cc74857b34376e2ccf74218d20687ac3</citedby><cites>FETCH-LOGICAL-c366t-9eb53e365d5c0101e9f4635602dba6352cc74857b34376e2ccf74218d20687ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/026765910101600405$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/026765910101600405$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11486848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muhle, Michelle L</creatorcontrib><creatorcontrib>Stammers, Alfred H</creatorcontrib><creatorcontrib>Tremain, Kimberly D</creatorcontrib><creatorcontrib>Niimi, Kevin S</creatorcontrib><creatorcontrib>Glogowski, Kimberly R</creatorcontrib><creatorcontrib>Trowbridge, Cody C</creatorcontrib><creatorcontrib>Yang, Tianyu</creatorcontrib><title>An in vitro study of the effects of isoflurane on oxygen transfer</title><title>Perfusion</title><addtitle>Perfusion</addtitle><description>A common anesthetic technique utilized during cardiopulmonary bypass (CPB) includes the use of various inhalation agents, such as isoflurane. The purpose of this study was to evaluate the effects of this agent on oxygen transfer during CPB.
An in vitro model was designed using bovine blood. Blood flow was held constant at 2 l/min, while gas flow was manipulated at 1 and 3 l/min. The percentage of inspired oxygen (FiO2) was set at 50 and 100%, and isoflurane was manipulated to 1.0, 3.0 and 5.0%. Blood gas analysis, oxygen transfer, and inlet and outlet isoflurane concentrations were measured at each of the given conditions. A total of 12 trials with four oxygenators were conducted.
In the four oxygenators used in our study, no significant differences in oxygenator performance were found. At conditions of 1 l/min gas flow, 50% FiO2 and 1% isoflurane, there were no significant changes in O2 transfer between baseline and measurements taken during isoflurane administration (100.18 ± 12.49 vs 102.35 ± 10.99 ml O2/min, p=0.8031). At 3 l/min gas flow, 100% FiO2 and 5% isoflurane, no significant differences were found (142.35 ± 10.76 vs 154.04 ± 8.95 ml O2/min, p=0.1459). The only significant differences found for oxygen transfer were between 50 and 100% FiO2, all other conditions being set equal (102.35 ± 10.99 vs 137.68 ± 8.62 ml O2/min, p=0.0023).
In conclusion, increasing concentrations of isoflurane up to 5% does not affect the efficiency of oxygen transfer in an in vitro circuit. Further studies are necessary to evaluate the effects in an in vivo setting.</description><subject>Anesthetics, Inhalation - pharmacology</subject><subject>Animals</subject><subject>Blood Flow Velocity</subject><subject>Blood Gas Analysis</subject><subject>Cattle</subject><subject>Dose-Response Relationship, Drug</subject><subject>Isoflurane - analysis</subject><subject>Isoflurane - pharmacology</subject><subject>Oxygen - metabolism</subject><subject>Oxygenators, Membrane</subject><issn>0267-6591</issn><issn>1477-111X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtLw0AUhQdRbK3-ARcyuHAXOzfzSpZFfEHBjYK7kEzu1JQ2U2cSsf_eCS0oitzF3APfPXM4hJwDuwbQespSpZXMgcVRjAkmD8gYhNYJALwekvEAJAMxIichLFlkhODHZAQgMpWJbExms5Y2Lf1oOu9o6Pp6S52l3RtStBZNFwbZBGdXvS9bpK6l7nO7wJZ2UQeL_pQc2XIV8Gz_TsjL3e3zzUMyf7p_vJnNE8OV6pIcK8mRK1lLMwTG3ArFpWJpXZVxSY3RIpO64oJrhVFaLVLI6pSpTJeGT8jVznfj3XuPoSvWTTC4WsVYrg-FBqZSUCqCl7_Apet9G7MVkOdSZnnOIpTuIONdCB5tsfHNuvTbAlgxtFv8bTceXeyd-2qN9ffJvs4ITHdAKBf449v_Lb8AfVp_tA</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Muhle, Michelle L</creator><creator>Stammers, Alfred H</creator><creator>Tremain, Kimberly D</creator><creator>Niimi, Kevin S</creator><creator>Glogowski, Kimberly R</creator><creator>Trowbridge, Cody C</creator><creator>Yang, Tianyu</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>An in vitro study of the effects of isoflurane on oxygen transfer</title><author>Muhle, Michelle L ; Stammers, Alfred H ; Tremain, Kimberly D ; Niimi, Kevin S ; Glogowski, Kimberly R ; Trowbridge, Cody C ; Yang, Tianyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-9eb53e365d5c0101e9f4635602dba6352cc74857b34376e2ccf74218d20687ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthetics, Inhalation - pharmacology</topic><topic>Animals</topic><topic>Blood Flow Velocity</topic><topic>Blood Gas Analysis</topic><topic>Cattle</topic><topic>Dose-Response Relationship, Drug</topic><topic>Isoflurane - analysis</topic><topic>Isoflurane - pharmacology</topic><topic>Oxygen - metabolism</topic><topic>Oxygenators, Membrane</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muhle, Michelle L</creatorcontrib><creatorcontrib>Stammers, Alfred H</creatorcontrib><creatorcontrib>Tremain, Kimberly D</creatorcontrib><creatorcontrib>Niimi, Kevin S</creatorcontrib><creatorcontrib>Glogowski, Kimberly R</creatorcontrib><creatorcontrib>Trowbridge, Cody C</creatorcontrib><creatorcontrib>Yang, Tianyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Perfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muhle, Michelle L</au><au>Stammers, Alfred H</au><au>Tremain, Kimberly D</au><au>Niimi, Kevin S</au><au>Glogowski, Kimberly R</au><au>Trowbridge, Cody C</au><au>Yang, Tianyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An in vitro study of the effects of isoflurane on oxygen transfer</atitle><jtitle>Perfusion</jtitle><addtitle>Perfusion</addtitle><date>2001-07</date><risdate>2001</risdate><volume>16</volume><issue>4</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>0267-6591</issn><eissn>1477-111X</eissn><abstract>A common anesthetic technique utilized during cardiopulmonary bypass (CPB) includes the use of various inhalation agents, such as isoflurane. The purpose of this study was to evaluate the effects of this agent on oxygen transfer during CPB.
An in vitro model was designed using bovine blood. Blood flow was held constant at 2 l/min, while gas flow was manipulated at 1 and 3 l/min. The percentage of inspired oxygen (FiO2) was set at 50 and 100%, and isoflurane was manipulated to 1.0, 3.0 and 5.0%. Blood gas analysis, oxygen transfer, and inlet and outlet isoflurane concentrations were measured at each of the given conditions. A total of 12 trials with four oxygenators were conducted.
In the four oxygenators used in our study, no significant differences in oxygenator performance were found. At conditions of 1 l/min gas flow, 50% FiO2 and 1% isoflurane, there were no significant changes in O2 transfer between baseline and measurements taken during isoflurane administration (100.18 ± 12.49 vs 102.35 ± 10.99 ml O2/min, p=0.8031). At 3 l/min gas flow, 100% FiO2 and 5% isoflurane, no significant differences were found (142.35 ± 10.76 vs 154.04 ± 8.95 ml O2/min, p=0.1459). The only significant differences found for oxygen transfer were between 50 and 100% FiO2, all other conditions being set equal (102.35 ± 10.99 vs 137.68 ± 8.62 ml O2/min, p=0.0023).
In conclusion, increasing concentrations of isoflurane up to 5% does not affect the efficiency of oxygen transfer in an in vitro circuit. Further studies are necessary to evaluate the effects in an in vivo setting.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>11486848</pmid><doi>10.1177/026765910101600405</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0267-6591 |
| ispartof | Perfusion, 2001-07, Vol.16 (4), p.293-299 |
| issn | 0267-6591 1477-111X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71062166 |
| source | MEDLINE; SAGE Complete |
| subjects | Anesthetics, Inhalation - pharmacology Animals Blood Flow Velocity Blood Gas Analysis Cattle Dose-Response Relationship, Drug Isoflurane - analysis Isoflurane - pharmacology Oxygen - metabolism Oxygenators, Membrane |
| title | An in vitro study of the effects of isoflurane on oxygen transfer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T11%3A15%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20in%20vitro%20study%20of%20the%20effects%20of%20isoflurane%20on%20oxygen%20transfer&rft.jtitle=Perfusion&rft.au=Muhle,%20Michelle%20L&rft.date=2001-07&rft.volume=16&rft.issue=4&rft.spage=293&rft.epage=299&rft.pages=293-299&rft.issn=0267-6591&rft.eissn=1477-111X&rft_id=info:doi/10.1177/026765910101600405&rft_dat=%3Cproquest_cross%3E1082162221%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199558990&rft_id=info:pmid/11486848&rft_sage_id=10.1177_026765910101600405&rfr_iscdi=true |