Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease
The purpose of this study was to analyse key enzyme activities of the deltoid muscle (DM) in chronic obstructive pulmonary disease (COPD) patients. The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and...
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| creator | Gea, J.G Pasto, M Carmona, M.A Orozco-Levi, M Palomeque, J Broquetas, J |
| description | The purpose of this study was to analyse key enzyme activities of the deltoid muscle (DM) in chronic obstructive pulmonary disease (COPD) patients. The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and one enzyme related to the use of energy stores (creatine kinase (CK)) were determined in the DM of 10 patients with COPD and nine controls. Exercise capacity (cycloergometry) and the handgrip strength were also evaluated. Although exercise capacity was markedly reduced in COPD (57 +/- 20% predicted), their handgrip strength was relatively preserved (77 +/- 19% pred). The activity of LD was higher in the COPD patients (263.9 +/- 68.2 versus 184.4 +/- 46.5 mmol x min(-1) x g(-1), p |
| doi_str_mv | 10.1183/09031936.01.17509390 |
| format | Article |
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The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and one enzyme related to the use of energy stores (creatine kinase (CK)) were determined in the DM of 10 patients with COPD and nine controls. Exercise capacity (cycloergometry) and the handgrip strength were also evaluated. Although exercise capacity was markedly reduced in COPD (57 +/- 20% predicted), their handgrip strength was relatively preserved (77 +/- 19% pred). The activity of LD was higher in the COPD patients (263.9 +/- 68.2 versus 184.4 +/- 46.5 mmol x min(-1) x g(-1), p<0.01), with a similar trend for CS (67.3 +/- 33.3 versus 46.0 +/- 17.4 mmol x min(-1) x g(-1), p = 0.07). Interestingly, the activity of the latter enzyme was significantly higher than controls if only severe COPD patients were considered (81.8 +/- 31.2 mmol x min(-1) x g(-1), p < 0.01). PFK and CK activities were similar for controls and COPD. Chronic obstructive patients show a preserved or even increased (severe disease) oxidative capacity in their deltoid muscle. This coexists with a greater capacity in the anaerobic part of the glycolysis. These findings are different to those previously observed in muscles of the lower limbs.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.01.17509390</identifier><identifier>PMID: 11488330</identifier><language>eng</language><publisher>Leeds: Eur Respiratory Soc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Citrate (si)-Synthase - metabolism ; Creatine Kinase - metabolism ; Cross-Sectional Studies ; Energy Metabolism - physiology ; Exercise Test ; Female ; Forced Expiratory Volume - physiology ; Humans ; Isometric Contraction - physiology ; L-Lactate Dehydrogenase - metabolism ; Male ; Medical sciences ; Middle Aged ; Muscle, Skeletal - physiopathology ; Phosphofructokinases - metabolism ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Reference Values</subject><ispartof>The European respiratory journal, 2001-05, Vol.17 (5), p.939-945</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-27fc0e913562e81d08cd8136f45883d573c02fb2aea603f5725441a43ebd9d013</citedby><cites>FETCH-LOGICAL-c408t-27fc0e913562e81d08cd8136f45883d573c02fb2aea603f5725441a43ebd9d013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1045877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11488330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gea, J.G</creatorcontrib><creatorcontrib>Pasto, M</creatorcontrib><creatorcontrib>Carmona, M.A</creatorcontrib><creatorcontrib>Orozco-Levi, M</creatorcontrib><creatorcontrib>Palomeque, J</creatorcontrib><creatorcontrib>Broquetas, J</creatorcontrib><title>Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>The purpose of this study was to analyse key enzyme activities of the deltoid muscle (DM) in chronic obstructive pulmonary disease (COPD) patients. The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and one enzyme related to the use of energy stores (creatine kinase (CK)) were determined in the DM of 10 patients with COPD and nine controls. Exercise capacity (cycloergometry) and the handgrip strength were also evaluated. Although exercise capacity was markedly reduced in COPD (57 +/- 20% predicted), their handgrip strength was relatively preserved (77 +/- 19% pred). The activity of LD was higher in the COPD patients (263.9 +/- 68.2 versus 184.4 +/- 46.5 mmol x min(-1) x g(-1), p<0.01), with a similar trend for CS (67.3 +/- 33.3 versus 46.0 +/- 17.4 mmol x min(-1) x g(-1), p = 0.07). Interestingly, the activity of the latter enzyme was significantly higher than controls if only severe COPD patients were considered (81.8 +/- 31.2 mmol x min(-1) x g(-1), p < 0.01). PFK and CK activities were similar for controls and COPD. Chronic obstructive patients show a preserved or even increased (severe disease) oxidative capacity in their deltoid muscle. This coexists with a greater capacity in the anaerobic part of the glycolysis. These findings are different to those previously observed in muscles of the lower limbs.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Citrate (si)-Synthase - metabolism</subject><subject>Creatine Kinase - metabolism</subject><subject>Cross-Sectional Studies</subject><subject>Energy Metabolism - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Humans</subject><subject>Isometric Contraction - physiology</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Phosphofructokinases - metabolism</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Reference Values</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1v1DAQhi1ERZfCP0DIB-CWZSZO4uSIKr6kVlzK2XLsCXHlxIvtUPHv69VuBae5PO8zMy9jbxD2iL34CAMIHES3B9yjbGEQAzxjOxTDUAkA8Zztjkh1ZC7Zy5TuAbBrBL5gl4hN3wsBOzbdUtZj8M5wM-uoTaboUnYm8TDxPBO35HNwli9bMp64W_lBZ0drTvzB5bnEYlhLPIwpx81k94f4YfNLWHX8y61LpBO9YheT9olen-cV-_nl8931t-rmx9fv159uKtNAn6taTgZoQNF2NfVooTe2R9FNTVvuta0UBupprDXpDsTUyrptGtSNoNEOFlBcsQ8n7yGG3xulrBaXDHmvVwpbUhKhAynaAjYn0MSQUqRJHaJbysUKQR37VU_9KkD11G-JvT37t3Eh-y90LrQA786ATkb7KerVuPSfvHwiZcHen7DZ_ZofXCSVFu19saKieI9StaosFI85S5Bz</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>Gea, J.G</creator><creator>Pasto, M</creator><creator>Carmona, M.A</creator><creator>Orozco-Levi, M</creator><creator>Palomeque, J</creator><creator>Broquetas, J</creator><general>Eur Respiratory Soc</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease</title><author>Gea, J.G ; Pasto, M ; Carmona, M.A ; Orozco-Levi, M ; Palomeque, J ; Broquetas, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-27fc0e913562e81d08cd8136f45883d573c02fb2aea603f5725441a43ebd9d013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Citrate (si)-Synthase - metabolism</topic><topic>Creatine Kinase - metabolism</topic><topic>Cross-Sectional Studies</topic><topic>Energy Metabolism - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Humans</topic><topic>Isometric Contraction - physiology</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Phosphofructokinases - metabolism</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gea, J.G</creatorcontrib><creatorcontrib>Pasto, M</creatorcontrib><creatorcontrib>Carmona, M.A</creatorcontrib><creatorcontrib>Orozco-Levi, M</creatorcontrib><creatorcontrib>Palomeque, J</creatorcontrib><creatorcontrib>Broquetas, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gea, J.G</au><au>Pasto, M</au><au>Carmona, M.A</au><au>Orozco-Levi, M</au><au>Palomeque, J</au><au>Broquetas, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>17</volume><issue>5</issue><spage>939</spage><epage>945</epage><pages>939-945</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>The purpose of this study was to analyse key enzyme activities of the deltoid muscle (DM) in chronic obstructive pulmonary disease (COPD) patients. The activities of one oxidative enzyme (citrate synthase (CS)), two glycolytic enzymes (lacatate dehydrogenase (LD); and phosphofructokinase (PFK)) and one enzyme related to the use of energy stores (creatine kinase (CK)) were determined in the DM of 10 patients with COPD and nine controls. Exercise capacity (cycloergometry) and the handgrip strength were also evaluated. Although exercise capacity was markedly reduced in COPD (57 +/- 20% predicted), their handgrip strength was relatively preserved (77 +/- 19% pred). The activity of LD was higher in the COPD patients (263.9 +/- 68.2 versus 184.4 +/- 46.5 mmol x min(-1) x g(-1), p<0.01), with a similar trend for CS (67.3 +/- 33.3 versus 46.0 +/- 17.4 mmol x min(-1) x g(-1), p = 0.07). Interestingly, the activity of the latter enzyme was significantly higher than controls if only severe COPD patients were considered (81.8 +/- 31.2 mmol x min(-1) x g(-1), p < 0.01). PFK and CK activities were similar for controls and COPD. Chronic obstructive patients show a preserved or even increased (severe disease) oxidative capacity in their deltoid muscle. This coexists with a greater capacity in the anaerobic part of the glycolysis. These findings are different to those previously observed in muscles of the lower limbs.</abstract><cop>Leeds</cop><pub>Eur Respiratory Soc</pub><pmid>11488330</pmid><doi>10.1183/09031936.01.17509390</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Chronic obstructive pulmonary disease, asthma Citrate (si)-Synthase - metabolism Creatine Kinase - metabolism Cross-Sectional Studies Energy Metabolism - physiology Exercise Test Female Forced Expiratory Volume - physiology Humans Isometric Contraction - physiology L-Lactate Dehydrogenase - metabolism Male Medical sciences Middle Aged Muscle, Skeletal - physiopathology Phosphofructokinases - metabolism Pneumology Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Reference Values |
| title | Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease |
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