Bacteremia in febrile Malawian children: clinical and microbiologic features
BACKGROUND. METHODS. RESULTS.Between September, 1996, and August, 1997, we processed 2123 cultures. Of these, 365 (17.2%) grew a pathogen. Non-typhi salmonellae (NTS) and enteric Gram-negative bacilli constituted 67.4% of isolates, and Streptococcus pneumoniae constituted 16.4%. More than two-thirds...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2000-04, Vol.19 (4), p.312-318 |
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| container_title | The Pediatric infectious disease journal |
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| creator | WALSH, AMANDA L PHIRI, AMOS J GRAHAM, STEPHEN M MOLYNEUX, ELIZABETH M MOLYNEUX, MALCOLM E |
| description | BACKGROUND.
METHODS.
RESULTS.Between September, 1996, and August, 1997, we processed 2123 cultures. Of these, 365 (17.2%) grew a pathogen. Non-typhi salmonellae (NTS) and enteric Gram-negative bacilli constituted 67.4% of isolates, and Streptococcus pneumoniae constituted 16.4%. More than two-thirds of NTS episodes coincided with the peak malaria transmission season (January to June); 67% of bacteremic children were malnourished, 28% severely so. Patients with NTS bacteremia were significantly more likely to have coincident malaria and to have splenomegaly and anemia than children with other infecting organisms. The overall mortality was 38% but varied considerably according to age and nutritional status. Prior antibiotic use, coincident malaria or meningitis did not adversely affect outcome. In vitro resistance to the commonly available antibiotics ampicillin and trimethoprim-sulfamethoxazole was found in 76 and 71% of NTS isolates. Screening tests for penicillin resistance suggested a rate of 21% among pneumococci.
CONCLUSIONS. |
| doi_str_mv | 10.1097/00006454-200004000-00010 |
| format | Article |
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METHODS.
RESULTS.Between September, 1996, and August, 1997, we processed 2123 cultures. Of these, 365 (17.2%) grew a pathogen. Non-typhi salmonellae (NTS) and enteric Gram-negative bacilli constituted 67.4% of isolates, and Streptococcus pneumoniae constituted 16.4%. More than two-thirds of NTS episodes coincided with the peak malaria transmission season (January to June); 67% of bacteremic children were malnourished, 28% severely so. Patients with NTS bacteremia were significantly more likely to have coincident malaria and to have splenomegaly and anemia than children with other infecting organisms. The overall mortality was 38% but varied considerably according to age and nutritional status. Prior antibiotic use, coincident malaria or meningitis did not adversely affect outcome. In vitro resistance to the commonly available antibiotics ampicillin and trimethoprim-sulfamethoxazole was found in 76 and 71% of NTS isolates. Screening tests for penicillin resistance suggested a rate of 21% among pneumococci.
CONCLUSIONS.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-200004000-00010</identifier><identifier>PMID: 10783021</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adolescent ; Africa - epidemiology ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; Bacteremia - diagnosis ; Bacteremia - drug therapy ; Bacteremia - epidemiology ; Bacteremia - microbiology ; Biological and medical sciences ; Child ; Child, Preschool ; Comorbidity ; Developing Countries ; Epidemiology. Vaccinations ; Female ; Fever of Unknown Origin - epidemiology ; General aspects ; Gram-Negative Bacterial Infections - diagnosis ; Gram-Negative Bacterial Infections - drug therapy ; Gram-Negative Bacterial Infections - epidemiology ; Gram-Negative Bacterial Infections - microbiology ; Gram-Positive Bacterial Infections - diagnosis ; Gram-Positive Bacterial Infections - drug therapy ; Gram-Positive Bacterial Infections - epidemiology ; Gram-Positive Bacterial Infections - microbiology ; Hospitalization ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infectious diseases ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Prospective Studies ; Risk Factors ; Survival Rate ; Tropical medicine</subject><ispartof>The Pediatric infectious disease journal, 2000-04, Vol.19 (4), p.312-318</ispartof><rights>Copyright © 2000 Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3850-422c68eccdc4eeb47a8c2e6ea21e2d5dcf156b749e75fd63be9aae9611d678843</citedby><cites>FETCH-LOGICAL-c3850-422c68eccdc4eeb47a8c2e6ea21e2d5dcf156b749e75fd63be9aae9611d678843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1352777$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10783021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WALSH, AMANDA L</creatorcontrib><creatorcontrib>PHIRI, AMOS J</creatorcontrib><creatorcontrib>GRAHAM, STEPHEN M</creatorcontrib><creatorcontrib>MOLYNEUX, ELIZABETH M</creatorcontrib><creatorcontrib>MOLYNEUX, MALCOLM E</creatorcontrib><title>Bacteremia in febrile Malawian children: clinical and microbiologic features</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND.
METHODS.
RESULTS.Between September, 1996, and August, 1997, we processed 2123 cultures. Of these, 365 (17.2%) grew a pathogen. Non-typhi salmonellae (NTS) and enteric Gram-negative bacilli constituted 67.4% of isolates, and Streptococcus pneumoniae constituted 16.4%. More than two-thirds of NTS episodes coincided with the peak malaria transmission season (January to June); 67% of bacteremic children were malnourished, 28% severely so. Patients with NTS bacteremia were significantly more likely to have coincident malaria and to have splenomegaly and anemia than children with other infecting organisms. The overall mortality was 38% but varied considerably according to age and nutritional status. Prior antibiotic use, coincident malaria or meningitis did not adversely affect outcome. In vitro resistance to the commonly available antibiotics ampicillin and trimethoprim-sulfamethoxazole was found in 76 and 71% of NTS isolates. Screening tests for penicillin resistance suggested a rate of 21% among pneumococci.
CONCLUSIONS.</description><subject>Adolescent</subject><subject>Africa - epidemiology</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteremia - diagnosis</subject><subject>Bacteremia - drug therapy</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - microbiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Comorbidity</subject><subject>Developing Countries</subject><subject>Epidemiology. Vaccinations</subject><subject>Female</subject><subject>Fever of Unknown Origin - epidemiology</subject><subject>General aspects</subject><subject>Gram-Negative Bacterial Infections - diagnosis</subject><subject>Gram-Negative Bacterial Infections - drug therapy</subject><subject>Gram-Negative Bacterial Infections - epidemiology</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Gram-Positive Bacterial Infections - diagnosis</subject><subject>Gram-Positive Bacterial Infections - drug therapy</subject><subject>Gram-Positive Bacterial Infections - epidemiology</subject><subject>Gram-Positive Bacterial Infections - microbiology</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Tropical medicine</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhi3UCpaPv4ByQL2F-tsON0D9khZxgbM1cSaswUmovdGq_76GXWgvWBrZh-edsZ4hpGL0nNHGfKXlaKlkzV9eslRditE9smBK8Jo21nwiC2obVgut7QE5zPmxIEIyuk8OGDVWUM4WZHkFfo0JhwBVGKse2xQiVjcQYRNgrPwqxC7heFH5GMbgIVYwdtUQfJraMMXpIfiSgvWcMB-Tzz3EjCe7-4jcf_92d_2zXt7--HV9uay9sIrWknOvLXrfeYnYSgPWc9QInCHvVOd7pnRrZING9Z0WLTYA2GjGOm2sleKIfNn2fU7T7xnz2g0he4wRRpzm7AyjyiomCmi3YPltzgl795zCAOmPY9S9mHRvJt27SfdqskRPdzPmdsDuv-BWXQHOdgDkoqVPMPqQ_3FCcWNMweQW20yxiM5Pcd5gciuEuF65jxYp_gJuCYra</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>WALSH, AMANDA L</creator><creator>PHIRI, AMOS J</creator><creator>GRAHAM, STEPHEN M</creator><creator>MOLYNEUX, ELIZABETH M</creator><creator>MOLYNEUX, MALCOLM E</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200004</creationdate><title>Bacteremia in febrile Malawian children: clinical and microbiologic features</title><author>WALSH, AMANDA L ; PHIRI, AMOS J ; GRAHAM, STEPHEN M ; MOLYNEUX, ELIZABETH M ; MOLYNEUX, MALCOLM E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3850-422c68eccdc4eeb47a8c2e6ea21e2d5dcf156b749e75fd63be9aae9611d678843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Africa - epidemiology</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteremia - diagnosis</topic><topic>Bacteremia - drug therapy</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - microbiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Comorbidity</topic><topic>Developing Countries</topic><topic>Epidemiology. Vaccinations</topic><topic>Female</topic><topic>Fever of Unknown Origin - epidemiology</topic><topic>General aspects</topic><topic>Gram-Negative Bacterial Infections - diagnosis</topic><topic>Gram-Negative Bacterial Infections - drug therapy</topic><topic>Gram-Negative Bacterial Infections - epidemiology</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Gram-Positive Bacterial Infections - diagnosis</topic><topic>Gram-Positive Bacterial Infections - drug therapy</topic><topic>Gram-Positive Bacterial Infections - epidemiology</topic><topic>Gram-Positive Bacterial Infections - microbiology</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WALSH, AMANDA L</creatorcontrib><creatorcontrib>PHIRI, AMOS J</creatorcontrib><creatorcontrib>GRAHAM, STEPHEN M</creatorcontrib><creatorcontrib>MOLYNEUX, ELIZABETH M</creatorcontrib><creatorcontrib>MOLYNEUX, MALCOLM E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WALSH, AMANDA L</au><au>PHIRI, AMOS J</au><au>GRAHAM, STEPHEN M</au><au>MOLYNEUX, ELIZABETH M</au><au>MOLYNEUX, MALCOLM E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteremia in febrile Malawian children: clinical and microbiologic features</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2000-04</date><risdate>2000</risdate><volume>19</volume><issue>4</issue><spage>312</spage><epage>318</epage><pages>312-318</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND.
METHODS.
RESULTS.Between September, 1996, and August, 1997, we processed 2123 cultures. Of these, 365 (17.2%) grew a pathogen. Non-typhi salmonellae (NTS) and enteric Gram-negative bacilli constituted 67.4% of isolates, and Streptococcus pneumoniae constituted 16.4%. More than two-thirds of NTS episodes coincided with the peak malaria transmission season (January to June); 67% of bacteremic children were malnourished, 28% severely so. Patients with NTS bacteremia were significantly more likely to have coincident malaria and to have splenomegaly and anemia than children with other infecting organisms. The overall mortality was 38% but varied considerably according to age and nutritional status. Prior antibiotic use, coincident malaria or meningitis did not adversely affect outcome. In vitro resistance to the commonly available antibiotics ampicillin and trimethoprim-sulfamethoxazole was found in 76 and 71% of NTS isolates. Screening tests for penicillin resistance suggested a rate of 21% among pneumococci.
CONCLUSIONS.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>10783021</pmid><doi>10.1097/00006454-200004000-00010</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Africa - epidemiology Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Bacteremia - diagnosis Bacteremia - drug therapy Bacteremia - epidemiology Bacteremia - microbiology Biological and medical sciences Child Child, Preschool Comorbidity Developing Countries Epidemiology. Vaccinations Female Fever of Unknown Origin - epidemiology General aspects Gram-Negative Bacterial Infections - diagnosis Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Gram-Positive Bacterial Infections - diagnosis Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology Gram-Positive Bacterial Infections - microbiology Hospitalization Humans Incidence Infant Infant, Newborn Infectious diseases Male Medical sciences Microbial Sensitivity Tests Prospective Studies Risk Factors Survival Rate Tropical medicine |
| title | Bacteremia in febrile Malawian children: clinical and microbiologic features |
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