Complete molecular remission during biologic response modifier therapy for Sézary syndrome is associated with enhanced helper T type 1 cytokine production and natural killer cell activity

Background: Cutaneous T-cell lymphoma (CTCL) is a clonally derived, skin-invasive malignancy of CD4+ T lymphocytes with the phenotype of mature helper T cells. Advancing stages of CTCL are associated with depressed cell-mediated immunity, increased production of T helper type 2 cytokines and decreas...

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Veröffentlicht in:	Journal of the American Academy of Dermatology 2001-08, Vol.45 (2), p.208-216
Hauptverfasser:	Yoo, Elisa K., Cassin, Maureen, Lessin, Stuart R., Rook, Alain H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - therapeutic use Biological and medical sciences Cytotoxicity, Immunologic Gene Rearrangement, T-Lymphocyte Genes, T-Cell Receptor beta - genetics Genes, T-Cell Receptor gamma - genetics Hematologic and hematopoietic diseases Humans Immunologic Factors - therapeutic use Interferon-alpha - therapeutic use Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Killer Cells, Natural - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Photopheresis Polymerase Chain Reaction Recombinant Proteins Sezary Syndrome - drug therapy Sezary Syndrome - genetics Sezary Syndrome - immunology Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - immunology T-Lymphocyte Subsets Th1 Cells - immunology Th1 Cells - metabolism
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