Induction of apoptosis in human colon carcinoma cells HT29 by sublethal cryo‐injury: Mediation by cytochrome c release

Cryosurgery is an emerging treatment for human solid tumors, notably colorectal liver metastasis. Cryosurgical procedures generate a thermal gradient of from at least −50°C at the center of the tumor being treated to about 0°C at the periphery. Cell death occurs by necrosis in the center, while the...

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