Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for cyclins E and A and arrests cells in the G1 phase of the cell cycle. Phosphorylation of Rb by cyclin D/cdk4 disrupts associati...

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Veröffentlicht in:	Cell 2000-03, Vol.101 (1), p.79-89
Hauptverfasser:	Zhang, H.Steven, Gavin, Mark, Dahiya, Anjali, Postigo, Antonio A, Ma, Duanduan, Luo, Robin X, Harbour, J.William, Dean, Douglas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Carrier Proteins - metabolism cdc2 gene CDC2-CDC28 Kinases cdk4 protein Cell Cycle Cell Division Cyclin A - genetics Cyclin D Cyclin E - genetics Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Cyclins - metabolism DNA Helicases Enzyme Inhibitors - pharmacology G1 Phase histone deacetylase Histone Deacetylase Inhibitors Histone Deacetylases - metabolism hSWI/SNF complex Humans Hydroxamic Acids - pharmacology Nuclear Proteins - metabolism Phosphorylation Promoter Regions, Genetic Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins Repressor Proteins - metabolism retinoblastoma protein Retinoblastoma Protein - metabolism S Phase Transcription Factors - metabolism Transcription, Genetic Transfection Tumor Cells, Cultured
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