The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis

It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation. Experimental data and theoretical considerations indicate that...

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Veröffentlicht in:	Journal of neurochemistry 2001-08, Vol.78 (3), p.515-523
Hauptverfasser:	Ross, Gregory M., Shamovsky, Igor L., Woo, Sang B., Post, Joan I., Vrkljan, Philip N., Lawrance, Gail, Solc, Mark, Dostaler, Suzanne M., Neet, Kenneth E., Riopelle, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - metabolism Animals Autoradiography Biological and medical sciences Brain Diseases - metabolism Copper - metabolism Humans Hydrogen-Ion Concentration Immunoblotting Injuries of the nervous system and the skull. Diseases due to physical agents Iodine Radioisotopes - metabolism Kinetics Medical sciences metalloproteins Mice Nerve Growth Factor - genetics Nerve Growth Factor - metabolism neurotrophin NGF PC12 Cells Phosphorylation Protein Binding Protein Conformation Rats Receptor, Nerve Growth Factor - chemistry Receptor, Nerve Growth Factor - isolation & purification Receptor, Nerve Growth Factor - metabolism Receptor, trkA - chemistry Receptor, trkA - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism Signal Transduction stroke Surface Plasmon Resonance transition metal cations Traumas. Diseases due to physical agents traumatic brain injury Zinc - metabolism
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