Analysis of MLH1 and MSH2 Expression in Ovarian Cancer before and after Platinum Drug-based Chemotherapy

Preclinical studies have demonstrated a relationship between DNA mismatch repair (MMR) status and sensitivity to cisplatin and carboplatin. MMR-deficient cells are resistant to both drugs, and selection for cisplatin resistance in vitro is sometimes accompanied by loss of MMR protein expression. We...

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Veröffentlicht in:	Clinical cancer research 2000-04, Vol.6 (4), p.1415-1421
Hauptverfasser:	SAMIMI, G, FINK, D, VARKI, N. M, HUSAIN, A, HOSKINS, W. J, ALBERTS, D. S, HOWELL, S. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences CA-125 Antigen - analysis Carboplatin - therapeutic use Carrier Proteins Chemotherapy Cisplatin - therapeutic use Data Interpretation, Statistical DNA-Binding Proteins Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Medical sciences MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Nuclear Proteins Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Pharmacology. Drug treatments Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - biosynthesis Tumors
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