Slow-Release 5-Fluorouracil and Triamcinolone Reduces Subglottic Stenosis in a Rabbit Model
A previous pilot study suggested that a sustained-release conjugate that provided a slow release of 5-fluorouracil and triamcinolone acetonide injected into the tracheal and paratracheal tissues of rabbits at the time of subglottic surgery reduced the formation of subglottic stenosis. Our study was...
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| Veröffentlicht in: | Annals of otology, rhinology & laryngology rhinology & laryngology, 2000-04, Vol.109 (4), p.422-424 |
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| container_title | Annals of otology, rhinology & laryngology |
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| creator | Ingrams, Duncan R. Ashton, Paul Shah, Rahul Dhingra, Jagdish Shapshay, Stanley M. |
| description | A previous pilot study suggested that a sustained-release conjugate that provided a slow release of 5-fluorouracil and triamcinolone acetonide injected into the tracheal and paratracheal tissues of rabbits at the time of subglottic surgery reduced the formation of subglottic stenosis. Our study was undertaken to confirm the effect. Ten milligrams of the compound suspended in hyaluronic acid was injected at the time of injury via a laryngofissure approach. The results showed that the control group had a mean stenosis of 52%, whereas the treated group had a mean stenosis of 32%. There was a significant difference between the treated and untreated groups (p = 003). It is hoped that this co-drug ultimately can be used in humans to reduce stenosis formation after laryngotracheal surgery and in other forms of otorhinolaryngological surgery. |
| doi_str_mv | 10.1177/000348940010900413 |
| format | Article |
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Our study was undertaken to confirm the effect. Ten milligrams of the compound suspended in hyaluronic acid was injected at the time of injury via a laryngofissure approach. The results showed that the control group had a mean stenosis of 52%, whereas the treated group had a mean stenosis of 32%. There was a significant difference between the treated and untreated groups (p = 003). 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Our study was undertaken to confirm the effect. Ten milligrams of the compound suspended in hyaluronic acid was injected at the time of injury via a laryngofissure approach. The results showed that the control group had a mean stenosis of 52%, whereas the treated group had a mean stenosis of 32%. There was a significant difference between the treated and untreated groups (p = 003). It is hoped that this co-drug ultimately can be used in humans to reduce stenosis formation after laryngotracheal surgery and in other forms of otorhinolaryngological surgery.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Delayed-Action Preparations</subject><subject>Drug Combinations</subject><subject>Fluorouracil - administration & dosage</subject><subject>Glottis</subject><subject>Injections</subject><subject>Laryngostenosis - drug therapy</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. 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Stomatology</topic><topic>Pilot Projects</topic><topic>Rabbits</topic><topic>Triamcinolone - administration & dosage</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ingrams, Duncan R.</creatorcontrib><creatorcontrib>Ashton, Paul</creatorcontrib><creatorcontrib>Shah, Rahul</creatorcontrib><creatorcontrib>Dhingra, Jagdish</creatorcontrib><creatorcontrib>Shapshay, Stanley M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Annals of otology, rhinology & laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ingrams, Duncan R.</au><au>Ashton, Paul</au><au>Shah, Rahul</au><au>Dhingra, Jagdish</au><au>Shapshay, Stanley M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Slow-Release 5-Fluorouracil and Triamcinolone Reduces Subglottic Stenosis in a Rabbit Model</atitle><jtitle>Annals of otology, rhinology & laryngology</jtitle><addtitle>Ann Otol Rhinol Laryngol</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>109</volume><issue>4</issue><spage>422</spage><epage>424</epage><pages>422-424</pages><issn>0003-4894</issn><eissn>1943-572X</eissn><coden>AORHA2</coden><abstract>A previous pilot study suggested that a sustained-release conjugate that provided a slow release of 5-fluorouracil and triamcinolone acetonide injected into the tracheal and paratracheal tissues of rabbits at the time of subglottic surgery reduced the formation of subglottic stenosis. Our study was undertaken to confirm the effect. Ten milligrams of the compound suspended in hyaluronic acid was injected at the time of injury via a laryngofissure approach. The results showed that the control group had a mean stenosis of 52%, whereas the treated group had a mean stenosis of 32%. There was a significant difference between the treated and untreated groups (p = 003). It is hoped that this co-drug ultimately can be used in humans to reduce stenosis formation after laryngotracheal surgery and in other forms of otorhinolaryngological surgery.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>10778898</pmid><doi>10.1177/000348940010900413</doi><tpages>3</tpages></addata></record> |
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| ispartof | Annals of otology, rhinology & laryngology, 2000-04, Vol.109 (4), p.422-424 |
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| subjects | Animals Biological and medical sciences Delayed-Action Preparations Drug Combinations Fluorouracil - administration & dosage Glottis Injections Laryngostenosis - drug therapy Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Pilot Projects Rabbits Triamcinolone - administration & dosage Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Slow-Release 5-Fluorouracil and Triamcinolone Reduces Subglottic Stenosis in a Rabbit Model |
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