Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension
It is well known that endothelin (ET)‐1 mediates vascular remodelling in various kinds of clinical and experimental pulmonary hypertension. The aim of this study was to investigate whether ET‐1 is associated with the development of pulmonary vascular remodelling in a canine model of chronic embolic...
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| Veröffentlicht in: | The European respiratory journal 2000-04, Vol.15 (4), p.640-648 |
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| creator | Kim, H Yung, GL Marsh, JJ Konopka, RG Pedersen, CA Chiles, PG Morris, TA Channick, RN |
| description | It is well known that endothelin (ET)‐1 mediates vascular remodelling in various kinds of clinical and experimental pulmonary hypertension. The aim of this study was to investigate whether ET‐1 is associated with the development of pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.
Pulmonary hypertension was induced in 10 mongrel dogs by repeated embolization with ceramic beads. In five of the dogs, bosentan, a nonselective ET receptor antagonist, was administered throughout the study. Haemodynamic measurements and plasma ET‐1 assays were performed every 2 months. Eight months after initial embolization, computer‐assisted morphometry and immunohistochemistry were performed on the lung tissue including that from three control dogs.
Pulmonary arterial pressure and pulmonary vascular resistance were increased in all embolized dogs, compared to baseline. In nontreated embolized dogs, plasma ET‐1 concentration and pulmonary arterial wall thickness were increased compared to control animals, and ET‐1 immunoreactivity was detected in thickened pulmonary arteries. In bosentan treated dogs, pulmonary arterial walls were not significantly thickened.
Pulmonary vascular remodelling, associated with elevated plasma endothelin‐1 levels and positive endothelin‐1 immunoreactivity in lung tissue is attenuated by the endothelin receptor antagonist, bosentan. These findings suggest that endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. |
| doi_str_mv | 10.1034/j.1399-3003.2000.15d04.x |
| format | Article |
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Pulmonary hypertension was induced in 10 mongrel dogs by repeated embolization with ceramic beads. In five of the dogs, bosentan, a nonselective ET receptor antagonist, was administered throughout the study. Haemodynamic measurements and plasma ET‐1 assays were performed every 2 months. Eight months after initial embolization, computer‐assisted morphometry and immunohistochemistry were performed on the lung tissue including that from three control dogs.
Pulmonary arterial pressure and pulmonary vascular resistance were increased in all embolized dogs, compared to baseline. In nontreated embolized dogs, plasma ET‐1 concentration and pulmonary arterial wall thickness were increased compared to control animals, and ET‐1 immunoreactivity was detected in thickened pulmonary arteries. In bosentan treated dogs, pulmonary arterial walls were not significantly thickened.
Pulmonary vascular remodelling, associated with elevated plasma endothelin‐1 levels and positive endothelin‐1 immunoreactivity in lung tissue is attenuated by the endothelin receptor antagonist, bosentan. These findings suggest that endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1034/j.1399-3003.2000.15d04.x</identifier><identifier>PMID: 10780753</identifier><language>eng</language><publisher>Sheffield: Eur Respiratory Soc</publisher><subject>Analysis of Variance ; Animals ; Antihypertensive Agents - pharmacology ; Biological and medical sciences ; Bosentan ; Chronic Disease ; chronic thromboembolic pulmonary hypertension ; Culture Techniques ; Disease Models, Animal ; Dogs ; Endothelin-1 - analysis ; Endothelin-1 - biosynthesis ; Female ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Hypertension, Pulmonary - diagnostic imaging ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - physiopathology ; Immunohistochemistry ; Lung - drug effects ; Lung - pathology ; Male ; Medical sciences ; morphometry ; Pneumology ; postobstructive pulmonary vasculopathy ; Probability ; Pulmonary Artery - drug effects ; Pulmonary Artery - pathology ; Pulmonary Circulation - drug effects ; Pulmonary Embolism - complications ; Pulmonary Embolism - diagnostic imaging ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Reference Values ; Sulfonamides - pharmacology ; Tomography, Emission-Computed ; Tropical medicine ; Vascular Resistance</subject><ispartof>The European respiratory journal, 2000-04, Vol.15 (4), p.640-648</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4754-3bd1fa35b5faa193e802ce8975042f7eb385123cf1538dedc0cce797640994f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1399-3003.2000.15d04.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1316058$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10780753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, H</creatorcontrib><creatorcontrib>Yung, GL</creatorcontrib><creatorcontrib>Marsh, JJ</creatorcontrib><creatorcontrib>Konopka, RG</creatorcontrib><creatorcontrib>Pedersen, CA</creatorcontrib><creatorcontrib>Chiles, PG</creatorcontrib><creatorcontrib>Morris, TA</creatorcontrib><creatorcontrib>Channick, RN</creatorcontrib><title>Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>It is well known that endothelin (ET)‐1 mediates vascular remodelling in various kinds of clinical and experimental pulmonary hypertension. The aim of this study was to investigate whether ET‐1 is associated with the development of pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.
Pulmonary hypertension was induced in 10 mongrel dogs by repeated embolization with ceramic beads. In five of the dogs, bosentan, a nonselective ET receptor antagonist, was administered throughout the study. Haemodynamic measurements and plasma ET‐1 assays were performed every 2 months. Eight months after initial embolization, computer‐assisted morphometry and immunohistochemistry were performed on the lung tissue including that from three control dogs.
Pulmonary arterial pressure and pulmonary vascular resistance were increased in all embolized dogs, compared to baseline. In nontreated embolized dogs, plasma ET‐1 concentration and pulmonary arterial wall thickness were increased compared to control animals, and ET‐1 immunoreactivity was detected in thickened pulmonary arteries. In bosentan treated dogs, pulmonary arterial walls were not significantly thickened.
Pulmonary vascular remodelling, associated with elevated plasma endothelin‐1 levels and positive endothelin‐1 immunoreactivity in lung tissue is attenuated by the endothelin receptor antagonist, bosentan. These findings suggest that endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bosentan</subject><subject>Chronic Disease</subject><subject>chronic thromboembolic pulmonary hypertension</subject><subject>Culture Techniques</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Endothelin-1 - analysis</subject><subject>Endothelin-1 - biosynthesis</subject><subject>Female</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Hypertension, Pulmonary - diagnostic imaging</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Immunohistochemistry</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphometry</subject><subject>Pneumology</subject><subject>postobstructive pulmonary vasculopathy</subject><subject>Probability</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Artery - pathology</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary Embolism - complications</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Reference Values</subject><subject>Sulfonamides - pharmacology</subject><subject>Tomography, Emission-Computed</subject><subject>Tropical medicine</subject><subject>Vascular Resistance</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EoqHwF5APwG3DOLb344KESvhSJSTUu-X1jruOvHaws7T59zjdiHLkNNL4mXfGDyGUwZoBF-93a8a7ruIAfL0BKF05gFjfPyGrvw9PyQo64BXreH1BXuS8A2C14Ow5uWDQtNBIviJhG4Z4GNG7QCccnD5gpvvZTzHodKS_dTaz14kmnOKAvmC3tKCaGh1cQPrQpdFSM6YYnKE49dGX-pgxHveYDhiyi-EleWa1z_jqXC_JzeftzdXX6vrHl29XH68rIxopKt4PzGoue2m1Lh_AFjYG266RIDa2wZ63km24sUzydsDBgDHYdE0toOuE5Zfk3RK7T_HXjPmgJpdNOV8HjHNWDQPJ6poVsF1Ak2LOCa3aJzeVqxUDdVKtdupkVJ2MqpNq9aBa3ZfR1-cdc1_M_TO4uC3AmzNQJGpvkw7G5UeOsxpkW7APC3bnPB7_e7_a_vzO5CcQJeDtEjC62_HOJVR50t6Xs5jCtGNSCVXE8D861qlR</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>Kim, H</creator><creator>Yung, GL</creator><creator>Marsh, JJ</creator><creator>Konopka, RG</creator><creator>Pedersen, CA</creator><creator>Chiles, PG</creator><creator>Morris, TA</creator><creator>Channick, RN</creator><general>Eur Respiratory Soc</general><general>Munksgaard International Publishers</general><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200004</creationdate><title>Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension</title><author>Kim, H ; Yung, GL ; Marsh, JJ ; Konopka, RG ; Pedersen, CA ; Chiles, PG ; Morris, TA ; Channick, RN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4754-3bd1fa35b5faa193e802ce8975042f7eb385123cf1538dedc0cce797640994f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bosentan</topic><topic>Chronic Disease</topic><topic>chronic thromboembolic pulmonary hypertension</topic><topic>Culture Techniques</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Endothelin-1 - analysis</topic><topic>Endothelin-1 - biosynthesis</topic><topic>Female</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Hypertension, Pulmonary - diagnostic imaging</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Immunohistochemistry</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphometry</topic><topic>Pneumology</topic><topic>postobstructive pulmonary vasculopathy</topic><topic>Probability</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Artery - pathology</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary Embolism - complications</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Reference Values</topic><topic>Sulfonamides - pharmacology</topic><topic>Tomography, Emission-Computed</topic><topic>Tropical medicine</topic><topic>Vascular Resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, H</creatorcontrib><creatorcontrib>Yung, GL</creatorcontrib><creatorcontrib>Marsh, JJ</creatorcontrib><creatorcontrib>Konopka, RG</creatorcontrib><creatorcontrib>Pedersen, CA</creatorcontrib><creatorcontrib>Chiles, PG</creatorcontrib><creatorcontrib>Morris, TA</creatorcontrib><creatorcontrib>Channick, RN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, H</au><au>Yung, GL</au><au>Marsh, JJ</au><au>Konopka, RG</au><au>Pedersen, CA</au><au>Chiles, PG</au><au>Morris, TA</au><au>Channick, RN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2000-04</date><risdate>2000</risdate><volume>15</volume><issue>4</issue><spage>640</spage><epage>648</epage><pages>640-648</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>It is well known that endothelin (ET)‐1 mediates vascular remodelling in various kinds of clinical and experimental pulmonary hypertension. The aim of this study was to investigate whether ET‐1 is associated with the development of pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.
Pulmonary hypertension was induced in 10 mongrel dogs by repeated embolization with ceramic beads. In five of the dogs, bosentan, a nonselective ET receptor antagonist, was administered throughout the study. Haemodynamic measurements and plasma ET‐1 assays were performed every 2 months. Eight months after initial embolization, computer‐assisted morphometry and immunohistochemistry were performed on the lung tissue including that from three control dogs.
Pulmonary arterial pressure and pulmonary vascular resistance were increased in all embolized dogs, compared to baseline. In nontreated embolized dogs, plasma ET‐1 concentration and pulmonary arterial wall thickness were increased compared to control animals, and ET‐1 immunoreactivity was detected in thickened pulmonary arteries. In bosentan treated dogs, pulmonary arterial walls were not significantly thickened.
Pulmonary vascular remodelling, associated with elevated plasma endothelin‐1 levels and positive endothelin‐1 immunoreactivity in lung tissue is attenuated by the endothelin receptor antagonist, bosentan. These findings suggest that endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension.</abstract><cop>Sheffield</cop><pub>Eur Respiratory Soc</pub><pmid>10780753</pmid><doi>10.1034/j.1399-3003.2000.15d04.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis of Variance Animals Antihypertensive Agents - pharmacology Biological and medical sciences Bosentan Chronic Disease chronic thromboembolic pulmonary hypertension Culture Techniques Disease Models, Animal Dogs Endothelin-1 - analysis Endothelin-1 - biosynthesis Female Hemodynamics - drug effects Hemodynamics - physiology Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Immunohistochemistry Lung - drug effects Lung - pathology Male Medical sciences morphometry Pneumology postobstructive pulmonary vasculopathy Probability Pulmonary Artery - drug effects Pulmonary Artery - pathology Pulmonary Circulation - drug effects Pulmonary Embolism - complications Pulmonary Embolism - diagnostic imaging Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Reference Values Sulfonamides - pharmacology Tomography, Emission-Computed Tropical medicine Vascular Resistance |
| title | Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension |
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